Detailed information for compound 910809

Basic information

Technical information
  • TDR Targets ID: 910809
  • Name: N,N'-bis(4-chlorophenyl)butanediamide
  • MW: 337.201 | Formula: C16H14Cl2N2O2
  • H donors: 2 H acceptors: 2 LogP: 3.09 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)Cl)CCC(=O)Nc1ccc(cc1)Cl
  • InChi: 1S/C16H14Cl2N2O2/c17-11-1-5-13(6-2-11)19-15(21)9-10-16(22)20-14-7-3-12(18)4-8-14/h1-8H,9-10H2,(H,19,21)(H,20,22)
  • InChiKey: RWHCKMGDHPFAAC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,N'-bis(4-chlorophenyl)succinamide
  • ZINC00143413
  • AIDS343396
  • AIDS-343396
  • AN-329/13581046
  • Butanediamide, N,N'-bis(4-chlorophenyl)-
  • EU-0041922
  • Oprea1_402975
  • ARONIS021296
  • ST040604
  • Oprea1_122963

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1669 0.2486 0.8904
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1669 0.2486 0.3034
Schistosoma mansoni cathepsin F (C01 family) 0.1669 0.2486 0.3034
Brugia malayi Cathepsin L-like precursor 0.1669 0.2486 0.3034
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1669 0.2486 0.8904
Loa Loa (eye worm) hypothetical protein 0.3378 0.8194 1
Onchocerca volvulus 0.1669 0.2486 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1669 0.2486 0.8904
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1669 0.2486 0.8904
Entamoeba histolytica cysteine proteinase, putative 0.1162 0.0791 0.3182
Loa Loa (eye worm) ctsf protein 0.1669 0.2486 0.229
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1669 0.2486 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1669 0.2486 0.8904
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3919 1 1
Onchocerca volvulus 0.1669 0.2486 1
Echinococcus multilocularis cathepsin b 0.3378 0.8194 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1669 0.2486 0.229
Plasmodium falciparum cysteine proteinase falcipain 3 0.1669 0.2486 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1669 0.2486 0.8904
Trypanosoma cruzi cysteine peptidase, putative 0.3919 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1761 0.2792 1
Loa Loa (eye worm) cysteine protease 0.1669 0.2486 0.229
Echinococcus granulosus cathepsin l1 0.1162 0.0791 0.0965
Plasmodium vivax vivapain-2 0.1669 0.2486 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.3378 0.8194 0.8194
Brugia malayi Cathepsin L-like precursor 0.1669 0.2486 0.3034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1669 0.2486 0.8904
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3919 1 1
Brugia malayi Papain family cysteine protease containing protein 0.1669 0.2486 0.3034
Onchocerca volvulus 0.1669 0.2486 1
Onchocerca volvulus 0.1669 0.2486 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3919 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3378 0.8194 1
Trypanosoma cruzi cysteine peptidase, putative 0.3919 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3919 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.1162 0.0791 0.0965
Giardia lamblia Cathepsin B precursor 0.1761 0.2792 0.5
Echinococcus granulosus cathepsin b 0.3378 0.8194 1
Onchocerca volvulus 0.1669 0.2486 1
Onchocerca volvulus 0.1669 0.2486 1
Brugia malayi Cathepsin L-like precursor 0.1162 0.0791 0.0965
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1761 0.2792 0.2792
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3378 0.8194 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1669 0.2486 0.8904
Entamoeba histolytica cysteine proteinase, putative 0.1669 0.2486 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1669 0.2486 0.8904
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3919 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1669 0.2486 0.8904
Echinococcus multilocularis cathepsin b 0.3378 0.8194 1
Trypanosoma cruzi cruzipain precursor, putative 0.3919 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1669 0.2486 0.8904
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3919 1 1
Leishmania major cathepsin L-like protease 0.3919 1 1
Leishmania major cathepsin L-like protease 0.3919 1 1
Onchocerca volvulus Cathepsin L homolog 0.1669 0.2486 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3919 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3378 0.8194 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.1669 0.2486 0.3034
Brugia malayi cathepsin L-like precursor 0.1162 0.0791 0.0965
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.3378 0.8194 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3919 1 1
Brugia malayi Cathepsin L-like precursor 0.1669 0.2486 0.3034
Schistosoma mansoni cathepsin F (C01 family) 0.1162 0.0791 0.0965
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1669 0.2486 0.8904
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.3411 0.8305 0.8305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1669 0.2486 0.8904
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1669 0.2486 0.8904
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1669 0.2486 0.8904
Echinococcus granulosus cathepsin L cysteine proteinase 0.1669 0.2486 0.3034
Onchocerca volvulus Cathepsin L homolog 0.1669 0.2486 1
Brugia malayi Cathepsin L-like precursor 0.1162 0.0791 0.0965
Onchocerca volvulus 0.1669 0.2486 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1669 0.2486 0.8904
Brugia malayi Cathepsin L-like precursor 0.1669 0.2486 0.3034
Brugia malayi Cathepsin L-like precursor 0.1669 0.2486 0.3034
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1669 0.2486 0.8904
Echinococcus multilocularis cathepsin L cysteine protease 0.1669 0.2486 0.3034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3919 1 1
Brugia malayi Cathepsin L-like precursor 0.1669 0.2486 0.3034
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1761 0.2792 0.0407
Giardia lamblia Cathepsin B precursor 0.1761 0.2792 0.5
Toxoplasma gondii cathepsin B 0.1761 0.2792 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1669 0.2486 0.8904
Loa Loa (eye worm) fibroinase 0.1669 0.2486 0.229
Trypanosoma cruzi cysteine peptidase, putative 0.3919 1 1
Entamoeba histolytica cysteine protease, putative 0.1669 0.2486 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1669 0.2486 0.3034
Trypanosoma brucei cysteine peptidase C (CPC) 0.1761 0.2792 0.2792
Trypanosoma cruzi cysteine peptidase, putative 0.1669 0.2486 0.2486
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3919 1 1
Echinococcus granulosus cathepsin l1 0.1669 0.2486 0.3034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1669 0.2486 0.8904
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1761 0.2792 0.3408
Echinococcus granulosus cathepsin b 0.3378 0.8194 1
Plasmodium vivax vivapain-2 0.1669 0.2486 1
Trypanosoma cruzi major cysteine proteinase, putative 0.2667 0.5818 0.5818
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1669 0.2486 0.8904
Brugia malayi cathepsin B-like cysteine proteinase 0.3378 0.8194 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1669 0.2486 0.229
Loa Loa (eye worm) cathepsin B 0.1761 0.2792 0.2704
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.3919 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1669 0.2486 0.8904
Entamoeba histolytica cysteine proteinase, putative 0.1669 0.2486 1
Giardia lamblia Cathepsin B precursor 0.1761 0.2792 0.5
Echinococcus multilocularis cysteine protease 0.1669 0.2486 0.3034
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1669 0.2486 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1162 0.0791 0.2833
Schistosoma mansoni cathepsin F (C01 family) 0.1669 0.2486 0.3034
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1669 0.2486 0.8904
Echinococcus multilocularis cysteine protease 0.1669 0.2486 0.3034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1162 0.0791 0.2833
Loa Loa (eye worm) hypothetical protein 0.1669 0.2486 0.229
Onchocerca volvulus Cathepsin F homolog 0.1669 0.2486 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1669 0.2486 0.8904
Echinococcus multilocularis cathepsin L cysteine protease 0.1669 0.2486 0.3034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1669 0.2486 0.8904
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1669 0.2486 0.8904

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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