Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | DNA topoisomerase II, putative | Curated by TDR Targets | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | DNA topoisomerase II | 0.0093 | 0.3869 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2144 | 0.2144 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0164 | 1 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0068 | 0.1708 | 0.5 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0074 | 0.2282 | 0.131 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0098 | 0.4283 | 0.5 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0068 | 0.1708 | 0.5 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0098 | 0.4283 | 0.3563 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0098 | 0.4283 | 0.3563 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0164 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0074 | 0.2282 | 0.131 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0098 | 0.4283 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2144 | 0.2144 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0098 | 0.4283 | 0.4283 |
Leishmania major | 0.0164 | 1 | 1 | |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0164 | 1 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0068 | 0.1708 | 0.5 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0098 | 0.4283 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0164 | 1 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0098 | 0.4283 | 0.5 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0098 | 0.4283 | 0.3563 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0098 | 0.4283 | 0.3563 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0074 | 0.2282 | 0.131 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0164 | 1 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0048 | 0 | 0.5 |
Leishmania major | DNA topoisomerase ii | 0.0098 | 0.4283 | 0.2592 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0164 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0164 | 1 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0164 | 1 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0098 | 0.4283 | 0.3563 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
---|---|---|---|---|---|---|
catalytic activity (GO:0003824) | decreased (PATO:0000468) | inferred from enzyme inhibition (ECO:0000184) | Trypanosoma cruzi | 42324 | ||
Annotator: | millerja@u.washington.edu | Comment: | coumermycin A2 is slightly different from the more commonly used coumermycin A1 (see http://www.iupac.org/publications/pac/pdf/1971/pdf/2804x0571.pdf) | References: | 3020537 |