Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0667 | 0.5 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0667 | 0.5 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0667 | 0.5 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0667 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Binding affinity to 20S proteasome beta-1 subunit in intact human HeLa cells at 1 uM by Western blotting analysis | ChEMBL. | 18801655 | |
Activity (binding) | Binding affinity to 20S proteasome beta5 subunit in intact human HeLa cells at 1 uM by Western blotting analysis | ChEMBL. | 18801655 | |
Activity (binding) | Binding affinity to 20S proteasome beta2 subunit in human erythrocyte at 1 uM by Western blotting analysis | ChEMBL. | 18801655 | |
Activity (binding) | Binding affinity to 20S proteasome beta-1 subunit in human erythrocyte at 1 uM after 1 hr by Western blotting analysis | ChEMBL. | 18801655 | |
Activity (binding) | Inhibition of clasto-lactacystin binding to beta5 subunit of 20S proteasome in human HeLa cells at 1 uM by Western blotting analysis | ChEMBL. | 18801655 | |
Activity (binding) | Binding affinity to 20S proteasome beta5 subunit in human erythrocyte at 1 uM by Western blotting analysis | ChEMBL. | 18801655 | |
Activity (binding) | Binding affinity to 20S proteasome beta2 subunit in intact human HeLa cells at 1 uM by Western blotting analysis | ChEMBL. | 18801655 | |
Activity (binding) | Binding affinity to 20S proteasome beta5 subunit in human erythrocyte at 1 uM after 1 hr by Western blotting analysis | ChEMBL. | 18801655 | |
Activity (binding) | Binding affinity to 20S proteasome beta2 subunit in human HeLa cell extract at 1 uM by Western blotting analysis | ChEMBL. | 18801655 | |
Activity (binding) | Inhibition of MG132 binding to beta-1 subunit of 20S proteasome in human HeLa cells at 1 uM by Western blotting analysis | ChEMBL. | 18801655 | |
Activity (binding) | Binding affinity to 20S proteasome beta-1 subunit in human erythrocyte at 1 uM by Western blotting analysis | ChEMBL. | 18801655 | |
Activity (binding) | Binding affinity to 20S proteasome beta2 subunit in human erythrocyte at 1 uM after 0.5 hr by Western blotting analysis | ChEMBL. | 18801655 | |
Activity (binding) | Inhibition of MG132 binding to beta5 subunit of 20S proteasome in human HeLa cells at 1 uM by Western blotting analysis | ChEMBL. | 18801655 | |
Activity (binding) | Binding affinity to 20S proteasome beta5 subunit in human HeLa cell extract at 1 uM by Western blotting analysis | ChEMBL. | 18801655 | |
Activity (binding) | Binding affinity to 26S proteasome beta-1 subunit in human HeLa cell extract at 1 uM by Western blotting analysis | ChEMBL. | 18801655 | |
Activity (binding) | Inhibition of clasto-lactacystin binding to beta2 subunit of 20S proteasome in human HeLa cells at 1 uM by Western blotting analysis | ChEMBL. | 18801655 | |
Activity (binding) | Binding affinity to 20S proteasome beta-1 subunit in human erythrocyte at 1 uM after 0.5 hr by Western blotting analysis | ChEMBL. | 18801655 | |
Activity (binding) | Binding affinity to 20S proteasome beta5 subunit in human erythrocyte at 1 uM after 0.5 hr by Western blotting analysis | ChEMBL. | 18801655 | |
Activity (binding) | Binding affinity to 20S proteasome beta2 subunit in human erythrocyte at 1 uM after 1 hr by Western blotting analysis | ChEMBL. | 18801655 | |
IC50 (functional) | = 9.8 uM | Growth inhibition of human HeLa cells after 48 hrs by MTT assay | ChEMBL. | 18801655 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 18801655 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.