Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | chromobox protein 1 | 0.0077 | 0.0097 | 0.0089 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0024 | 0.0015 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.0083 | 0.0075 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0 | 0.5 |
Echinococcus multilocularis | chromobox protein 1 | 0.0077 | 0.0097 | 0.0089 |
Brugia malayi | PHD-finger family protein | 0.0032 | 0.0009 | 0.0009 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0105 | 0.0154 | 0.0145 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0045 | 0.0036 |
Brugia malayi | RNA binding protein | 0.007 | 0.0083 | 0.0083 |
Onchocerca volvulus | 0.0034 | 0.0012 | 0.0003 | |
Plasmodium falciparum | phd finger protein, putative | 0.0032 | 0.0009 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0105 | 0.0154 | 0.0154 |
Brugia malayi | TAR-binding protein | 0.007 | 0.0083 | 0.0083 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0024 | 0.0015 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0045 | 0.0036 |
Onchocerca volvulus | 0.5073 | 1 | 1 | |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0066 | 0.0076 | 0.0076 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0039 | 0.0022 | 0.0013 |
Schistosoma mansoni | chromobox protein | 0.0077 | 0.0097 | 0.0089 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0083 | 0.0075 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0046 | 0.0037 | 0.0028 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.003 | 0.2714 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0045 | 0.0036 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0045 | 0.0045 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0045 | 0.0036 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0032 | 0.0009 | 0.0009 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.5073 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0039 | 0.0022 | 0.0013 |
Brugia malayi | hypothetical protein | 0.004 | 0.0024 | 0.0024 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.003 | 0.2714 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.0083 | 0.0083 |
Trichomonas vaginalis | chromobox protein, putative | 0.0077 | 0.0097 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0032 | 0.0009 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.5073 | 1 | 1 |
Schistosoma mansoni | chromobox protein | 0.0077 | 0.0097 | 0.0089 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0045 | 0.0036 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0077 | 0.0097 | 0.0097 |
Brugia malayi | Bromodomain containing protein | 0.0032 | 0.0009 | 0.0009 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.2057 | 0.4022 | 0.4017 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.003 | 0.003 |
Brugia malayi | MH2 domain containing protein | 0.0132 | 0.0206 | 0.0206 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0045 | 0.0036 |
Echinococcus granulosus | jumonji domain containing protein | 0.0045 | 0.0034 | 0.0025 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0132 | 0.0206 | 0.0206 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0012 | 0.0012 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.0083 | 0.0083 |
Echinococcus granulosus | chromobox protein 1 | 0.0077 | 0.0097 | 0.0089 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.3016 | 0.5923 | 0.5919 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0039 | 0.0022 | 0.0013 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0032 | 0.0009 | 1 |
Giardia lamblia | PHD finger protein 15 | 0.0032 | 0.0009 | 0.5 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.5073 | 1 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0105 | 0.0154 | 0.0145 |
Trichomonas vaginalis | chromobox protein, putative | 0.0046 | 0.0037 | 0.3419 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.0083 | 0.0075 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.5073 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0083 | 0.0075 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.0083 | 0.0083 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0045 | 0.0036 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0024 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0083 | 0.0075 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0039 | 0.0022 | 0.0013 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0083 | 0.0075 |
Trichomonas vaginalis | chromobox protein, putative | 0.0077 | 0.0097 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0077 | 0.0097 | 0.0097 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.5073 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0009 | 0.0009 |
Trichomonas vaginalis | chromobox protein, putative | 0.0046 | 0.0037 | 0.3419 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.5073 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0024 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.5073 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0024 | 0.0015 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0045 | 0.0045 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0132 | 0.0206 | 0.0206 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0083 | 0.0075 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0024 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0084 | 0.0111 | 0.0102 |
Echinococcus multilocularis | chromobox protein 1 | 0.0077 | 0.0097 | 0.0089 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0043 | 0.003 | 0.0022 |
Brugia malayi | jmjC domain containing protein | 0.0039 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0039 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0054 | 0.0054 |
Brugia malayi | chromobox protein homolog 3 | 0.0043 | 0.003 | 0.003 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.0083 | 0.0083 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.5073 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0024 | 0.0015 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0024 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0032 | 0.0009 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0045 | 0.0034 | 0.0025 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 50 umol/L | Cytotoxicity against human PC3 cells by resazurin reduction test | ChEMBL. | 19285391 |
IC50 (functional) | > 50 umol/L | Cytotoxicity against human MCF7 cells by resazurin reduction test | ChEMBL. | 19285391 |
IC50 (functional) | > 50 umol/L | Cytotoxicity against human DLD1 cells by resazurin reduction test | ChEMBL. | 19285391 |
IC50 (functional) | > 50 umol/L | Cytotoxicity against human A549 cells by resazurin reduction test | ChEMBL. | 19285391 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.