Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine protein kinase | 0.0486 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0206 | 0.0114 |
Schistosoma mansoni | cell adhesion molecule | 0.0027 | 0.0206 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0027 | 0.0206 | 0.0206 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0021 | 0.0094 | 0.0094 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0027 | 0.0206 | 0.0114 |
Echinococcus multilocularis | tyrosine protein kinase | 0.0486 | 1 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0027 | 0.0206 | 0.0114 |
Schistosoma mansoni | nephrin | 0.0027 | 0.0206 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0206 | 0.0206 |
Echinococcus multilocularis | roundabout 2 | 0.0027 | 0.0206 | 0.0206 |
Loa Loa (eye worm) | TK protein kinase | 0.0486 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0206 | 0.0206 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.9906 | 0.9906 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0206 | 0.0206 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 40 uM | Cytotoxic activity against human HL60 cells after 48 hrs by MTT assay | ChEMBL. | 20041704 |
IC50 (functional) | > 40 uM | Cytotoxic activity against human SMMC7721 cells after 48 hrs by MTT assay | ChEMBL. | 20041704 |
IC50 (functional) | > 40 uM | Cytotoxic activity against human A549 cells after 48 hrs by MTT assay | ChEMBL. | 20041704 |
IC50 (functional) | > 40 uM | Cytotoxic activity against human SK-BR-3 cells after 48 hrs by MTT assay | ChEMBL. | 20041704 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.