Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.1739 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.1739 | 1 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.1739 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.1511 | 0 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.1739 | 1 | 0.5 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.1511 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 23 uM | Antitrypanosomal activity against epimastigotes of Trypanosoma cruzi Tulahuen 2 assessed as parasite growth inhibition after 5 days | ChEMBL. | No reference |
ID50 (binding) | = 100 uM | Inhibition of Trypanosoma cruzi Cruzipain using Z-Phe-Arg-AMC as substrate measured for 10 mins by spectrofluorimetric analysis relative to control | ChEMBL. | No reference |
Inhibition (binding) | = 51 % | Inhibition of Trypanosoma cruzi Cruzipain using Z-Phe-Arg-AMC as substrate at 100 uM at pH 7.3 measured for 10 mins by spectrofluorimetric analysis relative to control | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.