Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0248 | 0.7413 | 0.7413 |
Onchocerca volvulus | Deterin homolog | 0.0288 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0156 | 0.1416 | 0.1416 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0156 | 0.1416 | 0.1416 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0134 | 0 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0134 | 0 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0248 | 0.7413 | 0.7413 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0156 | 0.1416 | 0.1911 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.7413 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0156 | 0.1416 | 0.1416 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0.7413 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.7413 | 0.5 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0156 | 0.1416 | 0.1416 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.7413 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0248 | 0.7413 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0248 | 0.7413 | 0.7413 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.7413 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0248 | 0.7413 | 0.7413 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0156 | 0.1416 | 0.1416 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0288 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0248 | 0.7413 | 0.7413 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0248 | 0.7413 | 0.7413 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0288 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0156 | 0.1416 | 0.1416 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 6.5 nM | Inhibition of human CA12 by CO2 hydration activity based stopped flow assay | ChEMBL. | 25022971 |
Ki (binding) | = 51.2 nM | Inhibition of human CA2 by CO2 hydration activity based stopped flow assay | ChEMBL. | 25022971 |
Ki (binding) | = 62.9 nM | Inhibition of human CA9 by CO2 hydration activity based stopped flow assay | ChEMBL. | 25022971 |
Ki (binding) | = 620 nM | Inhibition of human CA1 by CO2 hydration activity based stopped flow assay | ChEMBL. | 25022971 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.