Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | folate hydrolase (prostate-specific membrane antigen) 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Candida albicans | similar to transferrin receptor | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Candida albicans | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Schistosoma japonicum | ko:K01301 glutamate carboxypeptidase II [EC3.4.17.21], putative | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0103 | 0.5747 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0022 | 0.0297 | 0.043 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0022 | 0.0297 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0977 | 0.0701 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0032 | 0.0977 | 0.072 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0111 | 0.6234 | 0.6119 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0032 | 0.0977 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.5257 | 0.5111 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0121 | 0.6914 | 1 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0107 | 0.5976 | 0.8644 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0111 | 0.6234 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0022 | 0.0297 | 0.043 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0032 | 0.0977 | 0.1414 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0111 | 0.6234 | 0.6291 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0103 | 0.5747 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0032 | 0.0977 | 0.1414 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.6242 | 0.6127 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0121 | 0.6914 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0032 | 0.0977 | 0.072 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.9008 | 0.8977 |
Echinococcus granulosus | voltage gated potassium channel | 0.0032 | 0.0977 | 0.1145 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0022 | 0.0297 | 0.043 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0163 | 0.9734 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0022 | 0.0297 | 0.043 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0022 | 0.0297 | 0.043 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0111 | 0.6234 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0032 | 0.0977 | 0.1145 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 28.1 nM | Inhibition of human recombinant N-terminal Avi-tagged glutamate carboxypeptidase 2 extracellular domain (44 to 750 amino acids) using pteroyl-di-L-glutamate substrate by HPLC method | ChEMBL. | 24954515 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.