Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ROS proto-oncogene 1, receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tyrosine protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Echinococcus granulosus | tyrosine protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Loa Loa (eye worm) | TK protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.1636 | 0.3822 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0069 | 0.0935 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.0935 | 0.0935 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.0935 | 0.0935 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0006 | 0.0006 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0668 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.1636 | 0.3822 |
Echinococcus granulosus | tyrosine protein kinase | 0.029 | 0.4272 | 0.4272 |
Brugia malayi | Protein kinase domain containing protein | 0.029 | 0.4272 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0668 | 1 | 1 |
Echinococcus granulosus | smad | 0.0008 | 0.0006 | 0.0006 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0006 | 0.0006 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0006 | 0.0006 |
Echinococcus multilocularis | tyrosine protein kinase | 0.029 | 0.4272 | 0.4272 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.004 | 0.0493 | 0.0493 |
Echinococcus granulosus | transcription factor Dp 1 | 0.004 | 0.0493 | 0.0493 |
Echinococcus multilocularis | smad | 0.0008 | 0.0006 | 0.0006 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | TK protein kinase | 0.029 | 0.4272 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.0935 | 0.2178 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0006 | 0.0006 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.0935 | 0.5 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.1636 | 0.3822 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.0935 | 0.5 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0069 | 0.0935 | 0.2178 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0006 | 0.0006 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0006 | 0.0006 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0069 | 0.0935 | 0.5 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0006 | 0.0006 |
Schistosoma mansoni | smad | 0.0008 | 0.0006 | 0.0006 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.0935 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.4246 | 0.994 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0006 | 0.0006 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0006 | 0.0006 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.0935 | 0.0935 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 86.5 nM | Inhibition of ROS1 (unknown origin) assessed as remaining activity | ChEMBL. | 24997577 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.