Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.1522 | 0 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.1753 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.1753 | 1 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.1753 | 1 | 0.5 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.1522 | 0 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.1753 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 4 ug ml-1 | Antimicrobial activity against Candida albicans by two-fold serial dilution technique | ChEMBL. | 24930836 |
MIC (functional) | = 8 ug ml-1 | Antimicrobial activity against Saccharomyces cerevisiae by two-fold serial dilution technique | ChEMBL. | 24930836 |
MIC (functional) | = 16 ug ml-1 | Antimicrobial activity against Escherichia coli JM109 by two-fold serial dilution technique | ChEMBL. | 24930836 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.