Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0824 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0716 | 0 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0824 | 1 | 0.5 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0716 | 0 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0824 | 1 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0824 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 67 % | Inhibition of Escherichia coli MurF assessed as residual enzyme activity at 250 uM after 15 mins in presence of 0.005% Triton X-114 by Malachite green assay | ChEMBL. | 24953950 |
Activity (binding) | = 76 % | Inhibition of Escherichia coli MurE assessed as residual enzyme activity at 250 uM after 15 mins in presence of 0.005% Triton X-114 by Malachite green assay | ChEMBL. | 24953950 |
Activity (binding) | = 78 % | Inhibition of Escherichia coli MurD assessed as residual enzyme activity at 250 uM after 15 mins in presence of 0.005% Triton X-114 by Malachite green assay | ChEMBL. | 24953950 |
Activity (binding) | = 82 % | Inhibition of Escherichia coli MurC assessed as residual enzyme activity at 250 uM after 15 mins in presence of 0.005% Triton X-114 by Malachite green assay | ChEMBL. | 24953950 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.