Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.0635 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0154 | 0.0405 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0021 | 0.0097 | 0.0042 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0154 | 0.0098 |
Plasmodium falciparum | thioredoxin reductase | 0.0061 | 0.0789 | 1 |
Mycobacterium ulcerans | nitroreductase | 0.0052 | 0.0635 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0061 | 0.0789 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0154 | 0.0815 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0021 | 0.0097 | 0.0042 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0021 | 0.0097 | 0.0394 |
Loa Loa (eye worm) | glutathione reductase | 0.0061 | 0.0789 | 0.3036 |
Mycobacterium ulcerans | nitroreductase | 0.0052 | 0.0635 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0021 | 0.0097 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.0635 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.0635 | 1 |
Leishmania major | trypanothione reductase | 0.0061 | 0.0789 | 0.0737 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0097 | 0.0042 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0097 | 0.0042 |
Giardia lamblia | Nitroreductase Fd-NR2 | 0.0052 | 0.0635 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0146 | 0.2258 | 0.9141 |
Entamoeba histolytica | nitroreductase family protein | 0.0052 | 0.0635 | 0.5 |
Brugia malayi | bHLH-PAS transcription factor | 0.0035 | 0.0335 | 0.1356 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.0635 | 1 |
Mycobacterium tuberculosis | Probable F420 biosynthesis protein FbiB | 0.0052 | 0.0635 | 0.7776 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0021 | 0.0097 | 0.0716 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.0056 | 0.0226 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0154 | 0.0622 |
Mycobacterium tuberculosis | Conserved protein Acg | 0.0052 | 0.0635 | 0.7776 |
Brugia malayi | Thioredoxin reductase | 0.0061 | 0.0789 | 0.3194 |
Trypanosoma cruzi | nitroreductase | 0.0595 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.247 | 1 |
Mycobacterium leprae | Probable F420 biosynthesis protein FbiB | 0.0052 | 0.0635 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0061 | 0.0789 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.0056 | 0.0226 |
Entamoeba histolytica | hypothetical protein | 0.0052 | 0.0635 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.0635 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0021 | 0.0097 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0061 | 0.0789 | 0.3036 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0061 | 0.0789 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0097 | 0.0042 |
Giardia lamblia | Nitroreductase family protein fused to ferredoxin domain Fd-NR1 | 0.0052 | 0.0635 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.0635 | 1 |
Treponema pallidum | NADH oxidase | 0.0021 | 0.0097 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.0635 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.0635 | 1 |
Brugia malayi | hypothetical protein | 0.0159 | 0.247 | 1 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0021 | 0.0097 | 0.0042 |
Trypanosoma brucei | nitroreductase | 0.0595 | 1 | 1 |
Giardia lamblia | Nitroreductase family protein | 0.0052 | 0.0635 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0052 | 0.0635 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0097 | 0.0042 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0154 | 0.0098 |
Mycobacterium ulcerans | F420-0--gamma-glutamyl ligase | 0.0052 | 0.0635 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0097 | 0.0042 |
Echinococcus granulosus | single minded 2 | 0.0035 | 0.0335 | 0.3436 |
Trypanosoma brucei | Nitroreductase family, putative | 0.0052 | 0.0635 | 0.0582 |
Entamoeba histolytica | nitroreductase family protein | 0.0052 | 0.0635 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0021 | 0.0097 | 0.0716 |
Mycobacterium ulcerans | oxidoreductase | 0.0052 | 0.0635 | 1 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0021 | 0.0097 | 0.0042 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0021 | 0.0097 | 0.0042 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0154 | 0.0815 |
Mycobacterium tuberculosis | Putative oxidoreductase | 0.0052 | 0.0635 | 0.7776 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0154 | 0.0098 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.0635 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0097 | 0.0042 |
Brugia malayi | glutathione reductase | 0.0061 | 0.0789 | 0.3194 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.0635 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0021 | 0.0097 | 0.0042 |
Mycobacterium leprae | Possible oxidoreductase | 0.0052 | 0.0635 | 1 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0035 | 0.0335 | 0.3436 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0154 | 0.0098 |
Onchocerca volvulus | Iodotyrosine dehalogenase 1 homolog | 0.0052 | 0.0635 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0052 | 0.0635 | 0.0582 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0097 | 0.0042 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0154 | 0.0815 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0021 | 0.0097 | 0.0716 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0021 | 0.0097 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0061 | 0.0789 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0146 | 0.2258 | 0.9121 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0021 | 0.0097 | 0.0042 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0052 | 0.0635 | 0.7776 |
Brugia malayi | nitroreductase family protein | 0.0052 | 0.0635 | 0.2571 |
Mycobacterium tuberculosis | Conserved protein | 0.0052 | 0.0635 | 0.7776 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0021 | 0.0097 | 0.0042 |
Mycobacterium ulcerans | hypothetical protein | 0.0052 | 0.0635 | 1 |
Schistosoma mansoni | single-minded | 0.0047 | 0.0547 | 0.6505 |
Plasmodium vivax | glutathione reductase, putative | 0.0061 | 0.0789 | 1 |
Entamoeba histolytica | nitroreductase family protein | 0.0052 | 0.0635 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.0635 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0061 | 0.0789 | 0.0737 |
Mycobacterium ulcerans | putative regulatory protein | 0.0035 | 0.0335 | 0.4818 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0021 | 0.0097 | 0.0042 |
Mycobacterium ulcerans | nitroreductase | 0.0052 | 0.0635 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0061 | 0.0789 | 0.0737 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0047 | 0.0547 | 0.6505 |
Mycobacterium ulcerans | nitroreductase | 0.0052 | 0.0635 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.0635 | 1 |
Brugia malayi | PAS domain containing protein | 0.0047 | 0.0547 | 0.2215 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0021 | 0.0097 | 0.0042 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0154 | 0.0815 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.0635 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.0635 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0061 | 0.0789 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0061 | 0.0789 | 1 |
Trypanosoma brucei | Nitroreductase family, putative | 0.0052 | 0.0635 | 0.0582 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0004 | 0.0015 |
Trypanosoma cruzi | nitroreductase | 0.0595 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0635 | 0.2399 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 34.65 uM | Inhibition of human DPP-4 using H-Gly-Pro-para-Nitroanilide as substrate incubated for 20 mins prior to substrate addition measured after 30 mins by spectrophotometry | ChEMBL. | 24948564 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.