Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Reverse transcriptase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0259 | 0 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0259 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0713 | 0.2186 | 0.2186 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0259 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0881 | 0.2997 | 0.2997 |
Schistosoma mansoni | hypothetical protein | 0.2333 | 1 | 1 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0259 | 0 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0259 | 0 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0259 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0259 | 0 | 0.5 |
Echinococcus granulosus | indoleamine 23 dioxygenase 2 | 0.2333 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0622 | 0.1747 | 0.1747 |
Echinococcus multilocularis | indoleamine 2,3 dioxygenase 2 | 0.2333 | 1 | 1 |
Onchocerca volvulus | 0.0881 | 0.2997 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.2333 | 1 | 1 |
Entamoeba histolytica | aminopeptidase, putative | 0.0259 | 0 | 0.5 |
Loa Loa (eye worm) | indoleamine 2,3-dioxygenase | 0.2333 | 1 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.0881 | 0.2997 | 0.2997 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0259 | 0 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0259 | 0 | 0.5 |
Brugia malayi | Peptidase family M1 containing protein | 0.0881 | 0.2997 | 0.2997 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0259 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0259 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.079 | 0.2558 | 0.2558 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.49 uM | Inhibition of HIV-1 reverse transcriptase after 1 hr by ELISA plate reader analysis | ChEMBL. | 24953602 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.