Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0022 | 0.0213 | 0.0088 |
Schistosoma mansoni | nephrin | 0.0022 | 0.0213 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.0254 | 1 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0022 | 0.0213 | 0.0213 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0213 | 0.0213 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0213 | 0.0213 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0213 | 0.0213 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.9874 | 0.9874 |
Echinococcus granulosus | tyrosine protein kinase | 0.0254 | 1 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0022 | 0.0213 | 0.0088 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.002 | 0.0126 | 0.0126 |
Echinococcus granulosus | roundabout 2 | 0.0022 | 0.0213 | 0.0213 |
Echinococcus multilocularis | tyrosine protein kinase | 0.0254 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0213 | 0.0088 |
Schistosoma mansoni | cell adhesion molecule | 0.0022 | 0.0213 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 71.4 % | Inhibition of recombinant Grp94 (unknown origin) assessed as tracer bound at 25 uM after 24 hrs by fluorescence polarization assay relative to control | ChEMBL. | 25027801 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.