Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.4053 | 0.8169 |
Schistosoma mansoni | plexin | 0.0057 | 0.198 | 0.198 |
Loa Loa (eye worm) | plexin A | 0.0116 | 0.4961 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | semaphorin 1A | 0.0041 | 0.1165 | 0.1165 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.198 | 0.198 |
Entamoeba histolytica | protein kinase, putative | 0.0215 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0215 | 1 | 1 |
Brugia malayi | plexin A | 0.0116 | 0.4961 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0215 | 0.9996 | 0.9996 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1165 | 0.1165 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0215 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0023 | 0.0243 | 0.0243 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1165 | 0.2348 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1165 | 0.2348 |
Brugia malayi | Sema domain containing protein | 0.0041 | 0.1165 | 0.2348 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0215 | 0.9996 | 0.9996 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1165 | 0.2348 |
Brugia malayi | hypothetical protein | 0.0041 | 0.1165 | 0.2348 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0215 | 1 | 1 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0018 | 0 | 0.5 |
Brugia malayi | Sema domain containing protein | 0.0041 | 0.1165 | 0.2348 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0041 | 0.1165 | 0.2348 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0023 | 0.0243 | 0.0243 |
Brugia malayi | Plexin repeat family protein | 0.0098 | 0.4053 | 0.8169 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | hypothetical protein | 0.0041 | 0.1165 | 0.1165 |
Echinococcus granulosus | semaphorin 5B | 0.0041 | 0.1165 | 0.1165 |
Echinococcus granulosus | plexin a4 | 0.0116 | 0.4961 | 0.4961 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1165 | 0.2348 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1165 | 0.2348 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1165 | 0.2348 |
Onchocerca volvulus | 0.0098 | 0.4053 | 1 | |
Schistosoma mansoni | semaphorin 5-related | 0.0041 | 0.1165 | 0.1165 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0018 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0041 | 0.1165 | 0.2348 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0041 | 0.1165 | 0.2348 |
Echinococcus multilocularis | plexin a4 | 0.0116 | 0.4961 | 0.4961 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.198 | 0.3991 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1165 | 0.1165 |
Schistosoma mansoni | plexin | 0.0098 | 0.4053 | 0.4053 |
Echinococcus multilocularis | semaphorin 5B | 0.0041 | 0.1165 | 0.1165 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0.1 % | Inhibition of recombinant Grp94 (unknown origin) assessed as tracer bound at 25 uM after 24 hrs by fluorescence polarization assay relative to control | ChEMBL. | 25027801 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.