Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK protein kinase | 0.0257 | 0.0368 | 0.0368 |
Echinococcus granulosus | Nicastrin | 0.0111 | 0.0141 | 0.0141 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0228 | 0.0324 | 1 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0228 | 0.0324 | 0.076 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.0228 | 0.0324 | 0.076 |
Brugia malayi | Presenilin spe-4 | 0.008 | 0.0092 | 0.0092 |
Echinococcus multilocularis | Nicastrin | 0.0111 | 0.0141 | 0.0141 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.2504 | 0.3877 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.6426 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.008 | 0.0092 | 0.0092 |
Brugia malayi | hypothetical protein | 0.0111 | 0.0141 | 0.0141 |
Brugia malayi | Presenilin-like protein At2g29900 | 0.008 | 0.0092 | 0.0092 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0214 | 0.0302 | 0.0302 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.2504 | 0.3877 | 1 |
Brugia malayi | Presenilin spe-4 | 0.008 | 0.0092 | 0.0092 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0228 | 0.0324 | 1 |
Brugia malayi | hypothetical protein | 0.0111 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0141 | 0.0141 |
Echinococcus multilocularis | nicalin | 0.0041 | 0.0031 | 0.0031 |
Trypanosoma brucei | Presenilin enhancer-2 subunit of gamma secretase, putative | 0.0064 | 0.0068 | 0.0096 |
Echinococcus granulosus | tyrosine protein kinase | 0.0257 | 0.0368 | 0.0368 |
Toxoplasma gondii | hypothetical protein | 0.008 | 0.0092 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0228 | 0.0324 | 1 |
Echinococcus granulosus | nicalin | 0.0041 | 0.0031 | 0.0031 |
Schistosoma mansoni | hypothetical protein | 0.0111 | 0.0141 | 0.0141 |
Brugia malayi | hypothetical protein | 0.008 | 0.0092 | 0.0092 |
Trypanosoma brucei | Aph-1 protein, putative | 0.2504 | 0.3877 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.6426 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.0364 | 0.0364 |
Brugia malayi | Protein kinase domain containing protein | 0.0257 | 0.0368 | 0.0368 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0228 | 0.0324 | 0.076 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0214 | 0.0302 | 0.0302 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0214 | 0.0302 | 0.0302 |
Echinococcus multilocularis | presenilin | 0.0228 | 0.0324 | 0.0324 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.6426 | 1 | 1 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.6426 | 1 | 1 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0228 | 0.0324 | 0.0324 |
Brugia malayi | hypothetical protein | 0.008 | 0.0092 | 0.0092 |
Loa Loa (eye worm) | presenilin spe-4 | 0.008 | 0.0092 | 0.0092 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0214 | 0.0302 | 0.0302 |
Echinococcus multilocularis | tyrosine protein kinase | 0.0257 | 0.0368 | 0.0368 |
Echinococcus multilocularis | Nicastrin | 0.0111 | 0.0141 | 0.0141 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0228 | 0.0324 | 1 |
Brugia malayi | Presenilin family protein | 0.0228 | 0.0324 | 0.0324 |
Echinococcus granulosus | presenilin | 0.0228 | 0.0324 | 0.0324 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0228 | 0.0324 | 1 |
Brugia malayi | Presenilin spe-4 | 0.008 | 0.0092 | 0.0092 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 71 uM | Cytostatic activity against mouse L1210 cells assessed as inhibition of proliferation after 48 hrs by Coulter cell counting method | ChEMBL. | 24906510 |
IC50 (functional) | = 81 uM | Cytostatic activity against human CEM cells assessed as inhibition of proliferation after 72 hrs by Coulter cell counting method | ChEMBL. | 24906510 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.