Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | adenosine deaminase, putative | 0.0269 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0269 | 1 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.0269 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.0269 | 1 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0269 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0269 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0269 | 1 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.0269 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0269 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0269 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0269 | 1 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.0269 | 1 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.0269 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0269 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0269 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.0269 | 1 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0269 | 1 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.0269 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LC50 (ADMET) | = 69.2 uM | Cytotoxicity against mouse RAW264.7 cells assessed as cell viability by WST1 assay | ChEMBL. | 24897296 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.