Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase-activated protein kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Schistosoma japonicum | ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Brugia malayi | map kinase activated protein kinase protein 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase-activated protein kinase 2 | 370 aa | 303 aa | 26.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | MAP kinase sur-1 | 0.1062 | 0.9399 | 0.9399 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1062 | 0.9399 | 0.9399 |
Entamoeba histolytica | protein kinase, putative | 0.1114 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1062 | 0.9399 | 0.9399 |
Giardia lamblia | Aurora kinase | 0.1114 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1062 | 0.9399 | 0.829 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1062 | 0.9399 | 0.9399 |
Brugia malayi | cell division control protein 2 homolog | 0.0808 | 0.6487 | 0.6487 |
Schistosoma mansoni | protein kinase | 0.1114 | 1 | 1 |
Trypanosoma cruzi | aurora B kinase, putative | 0.1114 | 1 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.1114 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.1114 | 1 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.1114 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.1114 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase | 0.0808 | 0.6487 | 0.6487 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.1114 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1062 | 0.9399 | 0.829 |
Leishmania major | protein kinase, putative | 0.1114 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1062 | 0.9399 | 0.829 |
Echinococcus multilocularis | aurora kinase A | 0.1114 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0808 | 0.6487 | 0.6487 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.1114 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0781 | 0.6172 | 0.6172 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0808 | 0.6487 | 0.6487 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0808 | 0.6487 | 0.6487 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.1114 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0808 | 0.6487 | 0.6487 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1062 | 0.9399 | 0.829 |
Loa Loa (eye worm) | AUR protein kinase | 0.1114 | 1 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.1114 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0808 | 0.6487 | 0.6487 |
Trichomonas vaginalis | AGC family protein kinase | 0.1114 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0808 | 0.6487 | 0.6487 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1062 | 0.9399 | 0.829 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1062 | 0.9399 | 0.829 |
Brugia malayi | Protein kinase domain containing protein | 0.0808 | 0.6487 | 0.6487 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0808 | 0.6487 | 0.6487 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1062 | 0.9399 | 0.829 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.1114 | 1 | 1 |
Entamoeba histolytica | protein kinase , putative | 0.1114 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1062 | 0.9399 | 0.829 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1062 | 0.9399 | 0.9399 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1114 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0808 | 0.6487 | 0.6487 |
Trypanosoma brucei | protein kinase, putative | 0.1062 | 0.9399 | 0.829 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1062 | 0.9399 | 0.829 |
Brugia malayi | serine/threonine kinase 12 | 0.1114 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.1114 | 1 | 1 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.1114 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1062 | 0.9399 | 0.9399 |
Trichomonas vaginalis | AGC family protein kinase | 0.1114 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1114 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0808 | 0.6487 | 0.6487 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1062 | 0.9399 | 0.829 |
Toxoplasma gondii | aurora kinase | 0.1114 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1062 | 0.9399 | 0.829 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1062 | 0.9399 | 0.829 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0808 | 0.6487 | 0.6487 |
Echinococcus granulosus | aurora kinase A | 0.1114 | 1 | 1 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.1114 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1062 | 0.9399 | 0.9399 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0808 | 0.6487 | 0.6487 |
Trichomonas vaginalis | AGC family protein kinase | 0.1114 | 1 | 1 |
Trypanosoma brucei | aurora B kinase | 0.1114 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1062 | 0.9399 | 0.829 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0808 | 0.6487 | 0.6487 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 26 nM | Inhibition of MK2 (unknown origin) incubated for 30 mins by MK2 IMAP assay | ChEMBL. | 24913714 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.