Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0428 | 0.0695 | 1 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.4542 | 1 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0428 | 0.0695 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.177 | 0.373 | 1 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0402 | 0.0636 | 0.0446 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0402 | 0.0636 | 0.0446 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0428 | 0.0695 | 0.0507 |
Brugia malayi | Presenilin family protein | 0.0428 | 0.0695 | 0.0634 |
Brugia malayi | hypothetical protein | 0.0209 | 0.0199 | 0.0134 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0428 | 0.0695 | 0.5 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0428 | 0.0695 | 1 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0402 | 0.0636 | 0.0574 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.0428 | 0.0695 | 0.1864 |
Echinococcus multilocularis | presenilin | 0.0428 | 0.0695 | 0.0507 |
Brugia malayi | hypothetical protein | 0.0209 | 0.0199 | 0.0134 |
Trypanosoma brucei | Aph-1 protein, putative | 0.177 | 0.373 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0428 | 0.0695 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.177 | 0.373 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.4542 | 1 | 1 |
Echinococcus granulosus | presenilin | 0.0428 | 0.0695 | 0.0507 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0402 | 0.0636 | 0.0574 |
Toxoplasma gondii | hypothetical protein | 0.015 | 0.0066 | 1 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.4542 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.0199 | 0.0134 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.4542 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.2 nM | Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ level by FLIPR assay | ChEMBL. | 24948568 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.