Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0117 | 0.0104 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0858 | 0.1083 | 0.1076 |
Echinococcus granulosus | calcium release activated calcium channel | 0.761 | 1 | 1 |
Loa Loa (eye worm) | toll and interleukin 1 receptor domain-containing protein isoform f | 0.0117 | 0.0104 | 0.0104 |
Schistosoma mansoni | hypothetical protein | 0.0117 | 0.0104 | 0.0091 |
Brugia malayi | Serotonin receptor | 0.4857 | 0.6364 | 0.6361 |
Echinococcus granulosus | sterile alpha and tir motif containing protein | 0.0117 | 0.0104 | 0.0096 |
Echinococcus granulosus | Sterile alpha motif SAM | 0.0117 | 0.0104 | 0.0096 |
Echinococcus multilocularis | SAM domain containing protein | 0.0117 | 0.0104 | 0.0096 |
Schistosoma mansoni | tankyrase | 0.0117 | 0.0104 | 0.0091 |
Echinococcus multilocularis | calcium release activated calcium channel | 0.761 | 1 | 1 |
Onchocerca volvulus | 0.0117 | 0.0104 | 0.5 | |
Brugia malayi | hypothetical protein | 0.1477 | 0.19 | 0.1894 |
Echinococcus granulosus | liprin alpha 2 | 0.0117 | 0.0104 | 0.0096 |
Schistosoma mansoni | lar interacting protein (lip)-related protein | 0.0117 | 0.0104 | 0.0091 |
Schistosoma mansoni | Protein orai-1 | 0.761 | 1 | 1 |
Toxoplasma gondii | Tyrosine kinase-like (TKL) protein | 0.0117 | 0.0104 | 0.5 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0827 | 0.1042 | 0.1035 |
Plasmodium falciparum | protein kinase, putative | 0.0117 | 0.0104 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0676 | 0.0842 | 0.083 |
Schistosoma mansoni | sarm1 | 0.0117 | 0.0104 | 0.0091 |
Brugia malayi | coiled-coil like protein 1 | 0.0117 | 0.0104 | 0.0096 |
Brugia malayi | Liprin-alpha 2 | 0.0117 | 0.0104 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0104 | 0.0104 |
Echinococcus granulosus | stromal interaction molecule 1 | 0.1477 | 0.19 | 0.1894 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0104 | 0.0104 |
Brugia malayi | sterile alpha and TIR motif containing protein 1 isoform a | 0.0117 | 0.0104 | 0.0096 |
Plasmodium vivax | tyrosine kinase-like protein, putative | 0.0117 | 0.0104 | 0.5 |
Echinococcus granulosus | liprin beta 1 | 0.0117 | 0.0104 | 0.0096 |
Echinococcus multilocularis | sterile alpha and tir motif containing protein | 0.0117 | 0.0104 | 0.0096 |
Echinococcus granulosus | SAM domain containing protein | 0.0117 | 0.0104 | 0.0096 |
Echinococcus multilocularis | liprin beta 1 | 0.0117 | 0.0104 | 0.0096 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0117 | 0.0104 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0104 | 0.0104 |
Echinococcus multilocularis | tankyrase | 0.0117 | 0.0104 | 0.0096 |
Onchocerca volvulus | 0.0117 | 0.0104 | 0.5 | |
Plasmodium falciparum | tyrosine kinase-like protein | 0.0117 | 0.0104 | 0.5 |
Brugia malayi | Tnks protein | 0.0117 | 0.0104 | 0.0096 |
Echinococcus multilocularis | liprin alpha 2 | 0.0117 | 0.0104 | 0.0096 |
Schistosoma mansoni | hypothetical protein | 0.0117 | 0.0104 | 0.0091 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0104 | 0.0104 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0117 | 0.0104 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.761 | 1 | 1 |
Echinococcus granulosus | tankyrase | 0.0117 | 0.0104 | 0.0096 |
Brugia malayi | hypothetical protein | 0.0117 | 0.0104 | 0.0096 |
Schistosoma mansoni | hypothetical protein | 0.0801 | 0.1007 | 0.0995 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0117 | 0.0104 | 1 |
Schistosoma mansoni | Protein orai-1 | 0.761 | 1 | 1 |
Schistosoma mansoni | lip-related protein (liprin) alpha | 0.0117 | 0.0104 | 0.0091 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0044 | 0.0008 | 0.0008 |
Trichomonas vaginalis | c2h2 zinc finger protein, putative | 0.0117 | 0.0104 | 1 |
Echinococcus multilocularis | stromal interaction molecule 1 | 0.1477 | 0.19 | 0.1894 |
Schistosoma mansoni | hypothetical protein | 0.0117 | 0.0104 | 0.0091 |
Loa Loa (eye worm) | hypothetical protein | 0.1477 | 0.19 | 0.19 |
Brugia malayi | Neurabin protein 1 | 0.0117 | 0.0104 | 0.0096 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Growth inhibition of human SK-MEL-28 cells after 72 hrs by MTT assay | ChEMBL. | 24950030 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.