Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.1178 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0118 | 0 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.094 | 0.7754 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0488 | 0.3493 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0488 | 0.3493 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0118 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0118 | 0 | 0.5 |
Onchocerca volvulus | 0.0197 | 0.075 | 0.5 | |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0118 | 0 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0118 | 0 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.025 | 0.1247 | 0.031 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0118 | 0 | 0.5 |
Onchocerca volvulus | Putative sulfate transporter | 0.0197 | 0.075 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0118 | 0 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0118 | 0 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0488 | 0.3493 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0488 | 0.3493 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1178 | 1 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0118 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0466 | 0.3285 | 0.3344 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2230 nM | Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 24972108 |
Ki (binding) | = 3660 nM | Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cells | ChEMBL. | 24972108 |
Ki (binding) | = 5090 nM | Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 24972108 |
Ki (binding) | > 10000 nM | Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity | ChEMBL. | 24972108 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.