Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0585 | 1 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0523 | 0.8402 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0523 | 0.8402 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0585 | 1 | 0.5 |
Onchocerca volvulus | 0.0585 | 1 | 1 | |
Brugia malayi | acyl-CoA desaturase | 0.0523 | 0.8402 | 1 |
Onchocerca volvulus | 0.0585 | 1 | 1 | |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0523 | 0.8402 | 0.5 |
Schistosoma mansoni | fatty acid desaturase | 0.02 | 0 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.0585 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of synthetic activity of Streptococcus equisimilis RelA assessed as inhibition of (p)ppGpp accumulation at 5 to 10 mM after 5 mins | ChEMBL. | 20483622 | |
Inhibition (binding) | Inhibition of synthetic activity of Escherichia coli RelA assessed as inhibition of (p)ppGpp accumulation at 5 to 10 mM after 5 mins | ChEMBL. | 20483622 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.