Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.14694 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0967804 | 0.612814 | 0.612814 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.122648 | 0.812491 | 0.812491 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.14694 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.096951 | 0.614132 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0967804 | 0.612814 | 0.612814 |
Schistosoma mansoni | dihydrofolate reductase | 0.0967804 | 0.612814 | 0.612814 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.14694 | 1 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0635209 | 0.356083 | 0.356083 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0635209 | 0.356083 | 0.356083 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0635209 | 0.356083 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0967804 | 0.612814 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0967804 | 0.612814 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0635209 | 0.356083 | 0.579815 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0967804 | 0.612814 | 0.5 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0635209 | 0.356083 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0543948 | 0.285638 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.14694 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0967804 | 0.612814 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0967804 | 0.612814 | 0.612814 |
Brugia malayi | hypothetical protein | 0.0499891 | 0.25163 | 0.25163 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.122648 | 0.812491 | 0.812491 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.14694 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0499891 | 0.25163 | 0.409733 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0967804 | 0.612814 | 0.997855 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.14694 | 1 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.14694 | 1 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0635209 | 0.356083 | 0.356083 |
Brugia malayi | prolyl oligopeptidase family protein | 0.14694 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0543948 | 0.285638 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0635209 | 0.356083 | 0.356083 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.14694 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0967804 | 0.612814 | 0.612814 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.122648 | 0.812491 | 0.812491 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 386.9 nM | Antimalarial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 assessed as parasitemia after 48 hrs by flow cytometry | ChEMBL. | 25038484 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 25038484 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.