Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 7 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | serotonin transporter | solute carrier family 6 (neurotransmitter transporter), member 7 | 636 aa | 607 aa | 41.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0079 | 0.0824 | 0.0784 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0096 | 0.1278 | 0.0495 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.3003 | 0.7029 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0159 | 0.3003 | 0.2375 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0096 | 0.1278 | 0.0495 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0096 | 0.1278 | 0.0495 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0159 | 0.3003 | 0.2375 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0079 | 0.0824 | 0.0784 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0159 | 0.3003 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0205 | 0.4273 | 0.3759 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.1278 | 0.2991 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0079 | 0.0824 | 0.0784 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0079 | 0.0824 | 0.0784 |
Toxoplasma gondii | prolyl endopeptidase | 0.0159 | 0.3003 | 1 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0414 | 1 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0205 | 0.4273 | 0.3759 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0205 | 0.4273 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0205 | 0.4273 | 0.3759 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0159 | 0.3003 | 0.7029 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0096 | 0.1278 | 0.0495 |
Echinococcus granulosus | prolyl endopeptidase | 0.0159 | 0.3003 | 0.2375 |
Trypanosoma brucei | prolyl endopeptidase | 0.0159 | 0.3003 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0159 | 0.3003 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0159 | 0.3003 | 0.2375 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0096 | 0.1278 | 0.2991 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0072 | 0.0638 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0128 | 0.218 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0205 | 0.4273 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0072 | 0.0638 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0079 | 0.0824 | 0.1928 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.1278 | 0.2991 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0205 | 0.4273 | 1 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0096 | 0.1278 | 0.0495 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0096 | 0.1278 | 0.0495 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0096 | 0.1278 | 0.2991 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0414 | 1 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0079 | 0.0824 | 0.0784 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.076 uM | Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay | ChEMBL. | 25037917 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.