Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase II | 0.0119 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1187 | 1 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0947 | 0.7754 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0119 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0492 | 0.3493 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0492 | 0.3493 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0119 | 0 | 0.5 |
Onchocerca volvulus | 0.0199 | 0.075 | 0.5 | |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0119 | 0 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0119 | 0 | 0.5 |
Onchocerca volvulus | Putative sulfate transporter | 0.0199 | 0.075 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0252 | 0.1247 | 0.031 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0119 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0119 | 0 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0119 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.047 | 0.3285 | 0.3344 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0119 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1187 | 1 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0492 | 0.3493 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0492 | 0.3493 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 87.5 % | Cytotoxicity against HEK293T cells assessed as cell viability at 5 uM after 48 hrs | ChEMBL. | 25027940 |
Activity (ADMET) | > 90 % | Toxicity against Saccharomyces cerevisiae 14328 assessed as cell viability at 5 uM after 48 hrs | ChEMBL. | 25027940 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.