Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | elongation factor Tu, putative | 0.0008 | 0.0301 | 0.0301 |
Trypanosoma brucei | EF-1-alpha | 0.0008 | 0.0301 | 0.0301 |
Leishmania major | elongation factor 1-alpha | 0.0045 | 1 | 1 |
Schistosoma mansoni | elongation factor tu (ef-tu) | 0.0008 | 0.0301 | 0.0301 |
Trypanosoma cruzi | elongation factor 1-alpha, putative | 0.0045 | 1 | 1 |
Onchocerca volvulus | 0.0045 | 1 | 0.5 | |
Loa Loa (eye worm) | elongation factor 1-alpha | 0.0045 | 1 | 1 |
Trypanosoma cruzi | elongation factor 1-alpha, putative | 0.0045 | 1 | 1 |
Plasmodium falciparum | elongation factor 1-alpha | 0.0045 | 1 | 1 |
Schistosoma mansoni | elongation factor tu (ef-tu) | 0.0008 | 0.0301 | 0.0301 |
Trichomonas vaginalis | sulfate adenylyltransferase subunit, putative | 0.0008 | 0.0301 | 0.0301 |
Plasmodium vivax | elongation factor Tu, mitochondrial precursor, putative | 0.0008 | 0.0301 | 0.0301 |
Treponema pallidum | elongation factor Tu | 0.0008 | 0.0301 | 0.5 |
Echinococcus multilocularis | elongation factor 1 alpha | 0.0045 | 1 | 1 |
Echinococcus granulosus | elongation factor 1 alpha | 0.0045 | 1 | 1 |
Leishmania major | elongation factor 1-alpha | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | elongation factor Tu1 | 0.0008 | 0.0301 | 0.0301 |
Leishmania major | elongation factor 1-alpha | 0.0045 | 1 | 1 |
Trypanosoma cruzi | elongation factor 1-alpha, putative | 0.0045 | 0.9991 | 0.9991 |
Trichomonas vaginalis | elongation factor 1-alpha, putative | 0.0043 | 0.9691 | 0.9691 |
Mycobacterium leprae | PROBABLE IRON-REGULATED ELONGATION FACTOR TU TUF (EF-TU) | 0.0008 | 0.0301 | 0.5 |
Leishmania major | elongation factor 1-alpha | 0.0045 | 1 | 1 |
Onchocerca volvulus | 0.0045 | 1 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.0301 | 0.0301 |
Echinococcus multilocularis | elongation factor tu (ef tu) | 0.0008 | 0.0301 | 0.0301 |
Giardia lamblia | Elongation factor 1-alpha | 0.0045 | 1 | 1 |
Echinococcus multilocularis | g1 to s phase transition protein | 0.0008 | 0.0301 | 0.0301 |
Leishmania major | elongation factor 1-alpha | 0.0045 | 1 | 1 |
Giardia lamblia | Elongation factor 1-alpha | 0.0045 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | elongation factor Tu | 0.0008 | 0.0301 | 0.5 |
Trichomonas vaginalis | translation factor, putative | 0.0045 | 1 | 1 |
Trypanosoma cruzi | elongation factor 1-alpha, putative | 0.0045 | 1 | 1 |
Entamoeba histolytica | elongation factor 1-alpha 1 | 0.0045 | 1 | 1 |
Leishmania major | elongation factor Tu, putative | 0.0008 | 0.0301 | 0.0301 |
Plasmodium falciparum | elongation factor Tu | 0.0008 | 0.0301 | 0.0301 |
Brugia malayi | elongation factor 1-alpha (EF-1-alpha) | 0.0045 | 1 | 1 |
Toxoplasma gondii | elongation factor Tu, putative | 0.0008 | 0.0301 | 0.0301 |
Chlamydia trachomatis | elongation factor Tu | 0.0008 | 0.0301 | 0.5 |
Plasmodium falciparum | elongation factor 1-alpha | 0.0045 | 1 | 1 |
Brugia malayi | elongation factor Tu homologue precursor | 0.0008 | 0.0301 | 0.0301 |
Trypanosoma cruzi | elongation factor 1-alpha, putative | 0.0045 | 1 | 1 |
Plasmodium vivax | elongation factor 1-alpha, putative | 0.0045 | 1 | 1 |
Trichomonas vaginalis | translation factor, putative | 0.0045 | 0.9991 | 0.9991 |
Brugia malayi | Elongation factor Tu C-terminal domain containing protein | 0.0008 | 0.0301 | 0.0301 |
Trypanosoma brucei | elongation factor 1-alpha | 0.0045 | 1 | 1 |
Trichomonas vaginalis | elongation factor 1-alpha, putative | 0.0045 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | elongation factor Tu | 0.0008 | 0.0301 | 0.5 |
Toxoplasma gondii | elongation factor 1-alpha (EF-1-ALPHA), putative | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic translation elongation factor 1A | 0.0045 | 1 | 1 |
Trypanosoma brucei | elongation factor 1-alpha | 0.0045 | 1 | 1 |
Echinococcus granulosus | elongation factor tu ef tu | 0.0008 | 0.0301 | 0.0301 |
Toxoplasma gondii | elongation factor tu, apicoplast, putative | 0.0008 | 0.0301 | 0.0301 |
Toxoplasma gondii | elongation factor 1-alpha (EF-1-ALPHA), putative | 0.0045 | 1 | 1 |
Entamoeba histolytica | elongation factor 1-alpha 1 | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | elongation factor Tu domain-containing protein | 0.0008 | 0.0301 | 0.0301 |
Entamoeba histolytica | elongation factor 1-alpha 1 | 0.0045 | 1 | 1 |
Trypanosoma brucei | elongation factor 1-alpha | 0.0045 | 1 | 1 |
Leishmania major | elongation factor 1-alpha | 0.0045 | 1 | 1 |
Trypanosoma cruzi | elongation factor 1-alpha, putative | 0.0045 | 1 | 1 |
Schistosoma mansoni | elongation factor 1-alpha (ef-1-alpha) | 0.0008 | 0.0292 | 0.0292 |
Echinococcus granulosus | g1 to s phase transition protein | 0.0008 | 0.0301 | 0.0301 |
Trypanosoma cruzi | elongation factor 1-alpha, putative | 0.0045 | 1 | 1 |
Leishmania major | elongation factor 1-alpha | 0.0045 | 1 | 1 |
Mycobacterium ulcerans | elongation factor Tu | 0.0008 | 0.0301 | 0.5 |
Schistosoma mansoni | elongation factor 1-alpha (ef-1-alpha) | 0.0045 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Antileishmanial activity against Leishmania major JISH118 promastigotes infected in human THP1 cells by Giemsa staining method | ChEMBL. | 25069019 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.