Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | fructose-bisphospatase II | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.4995 | 0.4995 |
Leishmania major | 0.0326 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.4995 | 0.4995 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0326 | 1 | 1 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0326 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0326 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0326 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0326 | 1 | 1 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0206 | 0.4995 | 0.4995 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0326 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of human recombinant carboxy-terminal His-tagged LDHA by UV endpoint assay | ChEMBL. | 25037916 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.