Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lactate dehydrogenase C | Starlite/ChEMBL | References |
Homo sapiens | lactate dehydrogenase B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | lactate dehydrogenase, putative | lactate dehydrogenase C | 332 aa | 307 aa | 29.6 % |
Entamoeba histolytica | malate dehydrogenase, putative | lactate dehydrogenase B | 334 aa | 300 aa | 22.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Toxoplasma gondii | lactate dehydrogenase LDH1 | 0.0111 | 1 | 0.5 |
Echinococcus multilocularis | L lactate dehydrogenase B chain | 0.0111 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable malate dehydrogenase Mdh | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | lactate dehydrogenase protein | 0.0111 | 1 | 1 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0111 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | lactate dehydrogenase protein | 0.0111 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Plasmodium falciparum | L-lactate dehydrogenase | 0.0111 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE MALATE DEHYDROGENASE MDH | 0.0043 | 0 | 0.5 |
Trypanosoma brucei | cytosolic malate dehydrogenase | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0111 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Trypanosoma cruzi | cytosolic malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Trypanosoma cruzi | glycosomal malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | lactate dehydrogenase a | 0.0111 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Toxoplasma gondii | lactate dehydrogenase LDH2 | 0.0111 | 1 | 0.5 |
Trypanosoma brucei | malate dehydrogenase-related | 0.0043 | 0 | 0.5 |
Trypanosoma cruzi | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | L lactate dehydrogenase B chain | 0.0111 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Trypanosoma cruzi | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Mycobacterium ulcerans | malate dehydrogenase | 0.0043 | 0 | 0.5 |
Trypanosoma cruzi | glycosomal malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | L lactate dehydrogenase | 0.0068 | 0.3641 | 0.3641 |
Plasmodium vivax | malate dehydrogenase, putative | 0.0111 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 1 | 1 |
Plasmodium vivax | lactate dehydrogenase | 0.0111 | 1 | 1 |
Entamoeba histolytica | malate dehydrogenase, putative | 0.0111 | 1 | 1 |
Leishmania major | malate dehydrogenase, putative | 0.0111 | 1 | 1 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | malate dehydrogenase | 0.0111 | 1 | 1 |
Chlamydia trachomatis | malate dehydrogenase | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Trypanosoma cruzi | cytosolic malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | lactate dehydrogenase a | 0.0111 | 1 | 1 |
Trypanosoma brucei | mitochondrial malate dehydrogenase | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0111 | 1 | 1 |
Schistosoma mansoni | L-lactate dehydrogenase | 0.0111 | 1 | 1 |
Trypanosoma cruzi | mitochondrial malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | L lactate dehydrogenase | 0.0068 | 0.3641 | 0.3641 |
Toxoplasma gondii | malate dehydrogenase MDH | 0.0111 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | malate dehydrogenase | 0.0111 | 1 | 0.5 |
Plasmodium falciparum | malate dehydrogenase | 0.0111 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Giardia lamblia | Malate dehydrogenase | 0.0043 | 0 | 0.5 |
Trypanosoma brucei | glycosomal malate dehydrogenase | 0.0043 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.9 uM | Inhibition of human recombinant carboxy-terminal His-tagged LDHB by UV endpoint assay | ChEMBL. | 25037916 |
IC50 (binding) | > 100 uM | Inhibition of human recombinant carboxy-terminal His-tagged LDHA by UV endpoint assay | ChEMBL. | 25037916 |
Kd (binding) | = 13 uM | Inhibition of human recombinant carboxy-terminal His-tagged LDHA by SPR assay | ChEMBL. | 25037916 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.