Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0085 | 0.2744 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.0766 | 0.5036 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0143 | 0.533 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0058 | 0.152 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.0915 | 0.6018 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0058 | 0.152 | 0.5 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0058 | 0.152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1626 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0143 | 0.533 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.142 | 0.934 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0058 | 0.152 | 0.5 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0058 | 0.152 | 0.8826 |
Loa Loa (eye worm) | glutamate receptor | 0.0049 | 0.1121 | 0.4364 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0248 | 1 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.1121 | 0.737 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0058 | 0.152 | 0.5 |
Brugia malayi | Probable DNA topoisomerase II | 0.0058 | 0.152 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0058 | 0.152 | 0.5 |
Schistosoma mansoni | DNA topoisomerase II | 0.0058 | 0.152 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0248 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0248 | 1 | 0.5 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0058 | 0.152 | 0.8776 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0143 | 0.533 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0058 | 0.152 | 0.8776 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0143 | 0.533 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.1626 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.1626 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.005 | 0.1173 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0058 | 0.152 | 0.5 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0248 | 1 | 0.5 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0248 | 1 | 0.5 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0248 | 1 | 0.5 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0143 | 0.533 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 140 nM | Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membrane preparation | ChEMBL. | 25017030 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.