Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.736 | 1 | 1 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0618 | 0.0562 | 0.5 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0618 | 0.0562 | 0.5 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.2868 | 0.3712 | 1 |
Brugia malayi | hypothetical protein | 0.0301 | 0.0119 | 0.0119 |
Echinococcus granulosus | presenilin enhancer 2 | 0.058 | 0.0509 | 0.0395 |
Echinococcus granulosus | presenilin | 0.0618 | 0.0562 | 0.0449 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.058 | 0.0509 | 0.0395 |
Toxoplasma gondii | hypothetical protein | 0.0216 | 0 | 0.5 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0618 | 0.0562 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0618 | 0.0562 | 1 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0618 | 0.0562 | 0.0449 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.058 | 0.0509 | 0.0509 |
Brugia malayi | Presenilin family protein | 0.0618 | 0.0562 | 0.0562 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.0119 | 0.0119 |
Trypanosoma brucei | Aph-1 protein, putative | 0.2868 | 0.3712 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.736 | 1 | 1 |
Echinococcus multilocularis | presenilin | 0.0618 | 0.0562 | 0.0449 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.2868 | 0.3712 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0618 | 0.0562 | 1 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.058 | 0.0509 | 0.0509 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.736 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0301 | 0.0119 | 0.0119 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.736 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Time (functional) | = 20 min | Antinociceptive effect in intrathecally dosed ICR-CD1 mouse assessed as peak time for antinociceptive effect by tail flick test | ChEMBL. | 24978316 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.