Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | biogenic amine 5HT receptor | 0.046 | 0.9989 | 0.9989 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.046 | 0.9989 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0401 | 0.8056 | 0.8065 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.046 | 0.9989 | 0.9989 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.0461 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antidepressant activity in C57BL/6J mouse assessed as decrease in the immobility at 1 mg/kg, ip administered as single dose measured for last 4 mins of test by forced swim test relative to vehicle-treated control | ChEMBL. | 25073094 | |
Activity (functional) | Antidepressant activity in C57BL/6J mouse assessed as decrease in the immobility at 10 mg/kg, ip administered as single dose measured for last 4 mins of test by tail suspension method relative to vehicle-treated control | ChEMBL. | 25073094 | |
Activity (functional) | Effect on core body temperature in C57BL/6J mouse at 0.3 to 1 mg/kg, ip administered as single dose | ChEMBL. | 25073094 | |
Activity (functional) | Antidepressant activity in C57BL/6J mouse assessed as decrease in the immobility at 1 mg/kg, ip administered as single dose measured for last 4 mins of test by tail suspension method relative to vehicle-treated control | ChEMBL. | 25073094 | |
EC50 (binding) | = 0.23 uM | Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay | ChEMBL. | 25073094 |
Emax (binding) | = 21 % | Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay relative to control | ChEMBL. | 25073094 |
IC50 (binding) | = 2.2 uM | Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay | ChEMBL. | 25073094 |
Imax (binding) | = 81 % | Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay relative to control | ChEMBL. | 25073094 |
Inhibition (functional) | Inhibition of 8-OH-DPAT-induced hypothermia in C57BL/6J mouse assessed as reduction in core body temperature at 1 mg/kg, ip administered 30 mins prior challenge as single dose | ChEMBL. | 25073094 | |
Inhibition (binding) | = -31 % | Displacement of [125I]CYP from 5-HT1B (unknown origin) at 1 uM after 120 mins | ChEMBL. | 25073094 |
Inhibition (binding) | = -10 % | Displacement of [125I]sauvagine from CRF1 (unknown origin) at 1 uM after 120 mins | ChEMBL. | 25073094 |
Inhibition (binding) | = -4 % | Displacement of [125I]-2-iodomelatonin from MT1 (unknown origin) at 1 uM after 60 mins | ChEMBL. | 25073094 |
Inhibition (binding) | = 0 % | Displacement of [3H]mesulergine from 5-HT2C (unknown origin) at 1 uM after 120 mins | ChEMBL. | 25073094 |
Inhibition (binding) | = 14 % | Displacement of [3H]imipramine from 5-HT transporter (unknown origin) at 1 uM after 60 mins | ChEMBL. | 25073094 |
Inhibition (binding) | = 15 % | Displacement of [3H]ketanserin from 5-HT2A (unknown origin) at 1 uM after 60 mins | ChEMBL. | 25073094 |
Kb (binding) | = 84 nM | Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as dissociation constant after 45 mins by HTRF assay | ChEMBL. | 25073094 |
Ki (binding) | = 0.7 nM | Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry | ChEMBL. | 25073094 |
Ki (binding) | > 1000 nM | Displacement of [3H]-8-OH-DPAT from human 5-HT1A expressed in CHO-K1 cells after 120 mins by scintillation spectrometry | ChEMBL. | 25073094 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.