Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sodium channel, voltage-gated, type IX, alpha subunit | Starlite/ChEMBL | References |
Homo sapiens | sodium channel, voltage-gated, type V, alpha subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0188 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0072 | 0 | 0.5 |
Treponema pallidum | flavodoxin | 0.0072 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0188 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0188 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0167 | 0.8159 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0072 | 0 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0116 | 0.3805 | 0.5 |
Echinococcus multilocularis | methionine synthase reductase | 0.0116 | 0.3805 | 0.2619 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0167 | 0.8159 | 0.8159 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0167 | 0.8159 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0188 | 1 | 1 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0091 | 0.1607 | 0.1607 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0188 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0188 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0167 | 0.8159 | 0.8159 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0188 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0093 | 0.1841 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0188 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0188 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0167 | 0.8159 | 0.8159 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0188 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0188 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0188 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0072 | 0 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0188 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0072 | 0 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0093 | 0.1841 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0188 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0116 | 0.3805 | 0.3805 |
Echinococcus granulosus | methionine synthase reductase | 0.0116 | 0.3805 | 0.2619 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0095 | 0.1964 | 0.0151 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0188 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0188 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0116 | 0.3805 | 0.2407 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0188 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0188 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0072 | 0 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0188 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0116 | 0.3805 | 0.3805 |
Brugia malayi | FAD binding domain containing protein | 0.0188 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0188 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 437 nM | Inhibition of human Nav1.7 channel expressed in HEK293 cells assessed as membrane potential after 60 mins by FLIPR assay | ChEMBL. | 25113934 |
IC50 (ADMET) | = 8033 nM | Inhibition of human Nav1.5 channel expressed in HEK293 cells assessed as membrane potential after 60 mins by FLIPR assay | ChEMBL. | 25113934 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.