Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hexose transporter, putative | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0101 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0101 | 1 | 1 |
Trypanosoma cruzi | hexose transporter, putative | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0101 | 1 | 1 |
Plasmodium falciparum | hexose transporter | 0.0101 | 1 | 0.5 |
Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0031 | 0 | 0.5 |
Trypanosoma cruzi | hexose transporter, putative | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0101 | 1 | 1 |
Trypanosoma cruzi | hexose transporter | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter 2A | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0101 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0101 | 1 | 1 |
Plasmodium vivax | hexose transporter | 0.0101 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0101 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0101 | 1 | 1 |
Leishmania major | glucose transporter, lmgt1 | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | sugar transporter | 0.0101 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0101 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter 1E | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0101 | 1 | 1 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0101 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0101 | 1 | 0.5 |
Leishmania major | glucose transporter, lmgt3 | 0.0031 | 0 | 0.5 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0101 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0031 | 0 | 0.5 |
Leishmania major | glucose transporter, lmgt2 | 0.0031 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 22.5 umol | Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.