Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.1724 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.0535 | 0.0365 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.1724 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0147 | 0.0177 | 1 |
Echinococcus granulosus | presenilin | 0.0419 | 0.1874 | 0.1415 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0394 | 0.1714 | 0.1565 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0419 | 0.1874 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0672 | 0.3446 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.1724 | 1 | 1 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0672 | 0.3446 | 1 |
Brugia malayi | hypothetical protein | 0.0204 | 0.0535 | 0.0365 |
Echinococcus multilocularis | presenilin | 0.0419 | 0.1874 | 0.1415 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0419 | 0.1874 | 1 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0394 | 0.1714 | 0.1565 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.0419 | 0.1874 | 0.5439 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0419 | 0.1874 | 0.5 |
Brugia malayi | hypothetical protein | 0.0204 | 0.0535 | 0.0365 |
Brugia malayi | Presenilin family protein | 0.0419 | 0.1874 | 0.1728 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0419 | 0.1874 | 0.1415 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0394 | 0.1714 | 0.1245 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0394 | 0.1714 | 0.1245 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0672 | 0.3446 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0419 | 0.1874 | 1 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0419 | 0.1874 | 1 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.1724 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 74 nM | Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay | ChEMBL. | 25100568 |
Inhibition (binding) | = 96 % | Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as ph 5.0-induced calcium flux at 30 uM by FLIPR assay | ChEMBL. | 25100568 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.