Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | fmrfamide receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | fmrfamide receptor | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0094 | 0.8792 | 1 | |
Echinococcus multilocularis | g protein coupled receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.7816 | 0.8662 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | dro:myosuppressin receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.7816 | 0.8662 |
Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | allatostatin A receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.7816 | 0.8662 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | adenoreceptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | alpha 1A adrenergic receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | orexin receptor type 2 | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | serotonin receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | somatostatin receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | G protein coupled receptor 139 | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.9023 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | dro:myosuppressin receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | g protein coupled receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | sex peptide receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | g-protein coupled receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | 7TM GPCR rhodopsin | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | fmrfamide receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | sex peptide receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | g protein coupled receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | 7tm_1 domain containing protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | histamine h1 receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | G-protein coupled receptor, putative | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | g-protein coupled receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | peptide allatostatin:somatostatin | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide FF receptor 2 | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide s receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | g protein coupled receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | orexin receptor type 2 | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | g protein coupled receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | allatostatin A receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | myosin xvIII | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | g protein coupled receptor | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | somatostatin receptor | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0043 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
%max (binding) | < 10 % | Displacement of [3H]-E2 from recombinant human ERalpha at 20 uM after 9 hrs by competitive binding assay relative to control | ChEMBL. | 25078314 |
%max (binding) | = 13 % | Transactivation of human ERalpha expressed in CV1 cells assessed as maximum activity at 20 uM after 24 hrs by luciferase reporter gene assay relative to 17beta-estradiol | ChEMBL. | 25078314 |
%max (binding) | = 38.5 % | Displacement of [3H]-E2 from recombinant human ERbeta at 20 uM after 9 hrs by competitive binding assay relative to control | ChEMBL. | 25078314 |
%max (binding) | = 44.8 % | Transactivation of human ERbeta expressed in CV1 cells assessed as maximum activity at 20 uM after 24 hrs by luciferase reporter gene assay relative to 17beta-estradiol | ChEMBL. | 25078314 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.