Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acyl-CoA desaturase | 0.2392 | 0 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.2614 | 1 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2614 | 1 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.2392 | 0 | 0.5 |
Onchocerca volvulus | 0.2614 | 1 | 0.5 | |
Leishmania major | fatty-acid desaturase, putative | 0.2614 | 1 | 0.5 |
Onchocerca volvulus | 0.2614 | 1 | 0.5 | |
Brugia malayi | acyl-CoA desaturase | 0.2392 | 0 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.2392 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 10 % | Displacement of [3H]naloxone from human MOP receptor expressed in CHO-K1 cells at 1 uM by scintillation proximity assay | ChEMBL. | 25147603 |
Inhibition (binding) | < 10 % | Displacement of [3H]nociceptin from human NOP receptor expressed in CHO-K1 cells at 1 uM by scintillation proximity assay | ChEMBL. | 25147603 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.