Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0474 | 0.7155 | 0.7155 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0165 | 0.2288 | 0.2288 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0655 | 1 | 1 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0474 | 0.7155 | 0.7155 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0165 | 0.2288 | 0.2288 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0165 | 0.2288 | 0.2288 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1974 | 0.1974 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0244 | 0.3522 | 0.3522 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0474 | 0.7155 | 0.7155 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0474 | 0.7155 | 0.7155 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0244 | 0.3522 | 0.3522 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0474 | 0.7155 | 0.7155 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.002 | 0 | 0.5 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0474 | 0.7155 | 0.7155 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0474 | 0.7155 | 0.7155 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0165 | 0.2288 | 0.2288 |
Toxoplasma gondii | hypothetical protein | 0.0145 | 0.1974 | 0.1974 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0655 | 1 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0474 | 0.7155 | 0.7155 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1974 | 0.1974 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0655 | 1 | 1 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0655 | 1 | 1 |
Schistosoma mansoni | voltage-gated cation channel | 0.0474 | 0.7155 | 0.7155 |
Onchocerca volvulus | Transient receptor potential cation channel trpm homolog | 0.002 | 0 | 0.5 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0474 | 0.7155 | 0.7155 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0474 | 0.7155 | 0.7155 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0655 | 1 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0244 | 0.3522 | 0.3522 |
Onchocerca volvulus | Transient receptor potential cation channel trpm homolog | 0.002 | 0 | 0.5 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0244 | 0.3522 | 0.3522 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0474 | 0.7155 | 0.7155 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0474 | 0.7155 | 0.7155 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0655 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0655 | 1 | 1 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0474 | 0.7155 | 0.7155 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0655 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.2288 | 0.2288 |
Leishmania major | 0.0655 | 1 | 1 | |
Toxoplasma gondii | fructose-bisphospatase I | 0.0244 | 0.3522 | 0.3522 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0474 | 0.7155 | 0.7155 |
Loa Loa (eye worm) | calcium channel | 0.0474 | 0.7155 | 0.7155 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0165 | 0.2288 | 0.2288 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 968 nM | Antiproliferative activity against human HT-29 cells | ChEMBL. | 25059503 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 25059503 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.