Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0633 | 0.1152 | 0.093 |
Onchocerca volvulus | 0.0633 | 0.1152 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0741 | 0.1527 | 0.4951 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.3185 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0741 | 0.1527 | 0.4951 |
Brugia malayi | Cathepsin L-like precursor | 0.0633 | 0.1152 | 0.093 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0454 | 0.0533 | 0.0296 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0633 | 0.1152 | 0.0654 |
Leishmania major | cathepsin L-like protease | 0.0741 | 0.1527 | 0.2226 |
Plasmodium vivax | vivapain-2 | 0.0633 | 0.1152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0371 | 0.0244 | 0.0244 |
Loa Loa (eye worm) | cathepsin B | 0.1118 | 0.2834 | 0.2431 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0633 | 0.1152 | 0.093 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Brugia malayi | Cathepsin L-like precursor | 0.0633 | 0.1152 | 0.093 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0633 | 0.1152 | 0.093 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Onchocerca volvulus | Cathepsin L homolog | 0.0633 | 0.1152 | 1 |
Toxoplasma gondii | cathepsin B | 0.1118 | 0.2834 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0562 | 0.0908 | 0.0908 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Onchocerca volvulus | Cathepsin F homolog | 0.0633 | 0.1152 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0454 | 0.0533 | 0.3182 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0633 | 0.1152 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0633 | 0.1152 | 0.0654 |
Entamoeba histolytica | cysteine protease, putative | 0.0633 | 0.1152 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.1118 | 0.2834 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0633 | 0.1152 | 0.093 |
Echinococcus multilocularis | cathepsin b | 0.3185 | 1 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0454 | 0.0533 | 0.0296 |
Onchocerca volvulus | 0.0633 | 0.1152 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0741 | 0.1527 | 0.4951 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0741 | 0.1527 | 0.4951 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3185 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.3185 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.3185 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3185 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.3185 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0741 | 0.1527 | 0.1527 |
Loa Loa (eye worm) | hypothetical protein | 0.3185 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0633 | 0.1152 | 0.093 |
Echinococcus granulosus | cathepsin b | 0.3185 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0633 | 0.1152 | 0.093 |
Onchocerca volvulus | 0.0633 | 0.1152 | 1 | |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0741 | 0.1527 | 0.1527 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0741 | 0.1527 | 0.4951 |
Onchocerca volvulus | Cathepsin L homolog | 0.0633 | 0.1152 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.0371 | 0.0244 | 0.0244 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.1118 | 0.2834 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0633 | 0.1152 | 0.093 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0633 | 0.1152 | 1 |
Onchocerca volvulus | 0.0633 | 0.1152 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Brugia malayi | Cathepsin L-like precursor | 0.0454 | 0.0533 | 0.0296 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Onchocerca volvulus | 0.0633 | 0.1152 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Brugia malayi | Cathepsin L-like precursor | 0.0633 | 0.1152 | 0.093 |
Brugia malayi | Cathepsin L-like precursor | 0.0633 | 0.1152 | 0.093 |
Loa Loa (eye worm) | hypothetical protein | 0.0633 | 0.1152 | 0.0654 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0633 | 0.1152 | 0.093 |
Leishmania major | cathepsin L-like protease | 0.0741 | 0.1527 | 0.2226 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3185 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0741 | 0.1527 | 0.4951 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0741 | 0.1527 | 0.4951 |
Brugia malayi | Cathepsin L-like precursor | 0.0633 | 0.1152 | 0.093 |
Giardia lamblia | Cathepsin B precursor | 0.1118 | 0.2834 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0741 | 0.1527 | 0.4951 |
Echinococcus granulosus | cathepsin l1 | 0.0633 | 0.1152 | 0.093 |
Onchocerca volvulus | 0.0633 | 0.1152 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0741 | 0.1527 | 0.1527 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.1118 | 0.2834 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1118 | 0.2834 | 0.2655 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Echinococcus granulosus | cathepsin l1 | 0.0454 | 0.0533 | 0.0296 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0371 | 0.0244 | 0.0244 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0454 | 0.0533 | 0.1115 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0741 | 0.1527 | 0.4951 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1118 | 0.2834 | 0.2834 |
Brugia malayi | Cathepsin L-like precursor | 0.0633 | 0.1152 | 0.093 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0633 | 0.1152 | 0.093 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0633 | 0.1152 | 0.093 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0454 | 0.0533 | 0.0296 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0633 | 0.1152 | 0.1152 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Giardia lamblia | Cathepsin B precursor | 0.1118 | 0.2834 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0454 | 0.0533 | 0.1115 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Loa Loa (eye worm) | ctsf protein | 0.0633 | 0.1152 | 0.0654 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0633 | 0.1152 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0454 | 0.0533 | 0.0296 |
Echinococcus multilocularis | cysteine protease | 0.0633 | 0.1152 | 0.093 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Onchocerca volvulus | 0.0633 | 0.1152 | 1 | |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0633 | 0.1152 | 0.0654 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0371 | 0.0244 | 0.0244 |
Plasmodium vivax | vivapain-2 | 0.0633 | 0.1152 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0741 | 0.1527 | 0.4951 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0633 | 0.1152 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0633 | 0.1152 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.1118 | 0.2834 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0741 | 0.1527 | 0.1527 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Loa Loa (eye worm) | cysteine protease | 0.0633 | 0.1152 | 0.0654 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0741 | 0.1527 | 0.4951 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0371 | 0.0244 | 0.0244 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0633 | 0.1152 | 0.3505 |
Leishmania major | cathepsin L-like protease | 0.0741 | 0.1527 | 0.2226 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 38 uM | Inhibition of Plasmodium falciparum SUB1 | ChEMBL. | 25129616 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.