Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | RAR-related orphan receptor C | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | frizzled | 0.0077 | 0.2208 | 0.302 |
Echinococcus granulosus | frizzled 5 | 0.0077 | 0.2208 | 0.302 |
Echinococcus multilocularis | secreted frizzled protein 5 | 0.0077 | 0.2208 | 0.302 |
Brugia malayi | Frizzled/Smoothened family membrane region containing protein | 0.0077 | 0.2208 | 0.302 |
Loa Loa (eye worm) | frizzled/Smoothened family membrane region containing protein | 0.0077 | 0.2208 | 0.302 |
Schistosoma mansoni | wnt inhibitor frzb2 | 0.0077 | 0.2208 | 0.302 |
Schistosoma mansoni | netrin | 0.0224 | 0.7312 | 1 |
Schistosoma mansoni | netrin | 0.0224 | 0.7312 | 1 |
Schistosoma mansoni | frizzled-like receptor | 0.0077 | 0.2208 | 0.302 |
Echinococcus granulosus | frizzled | 0.0077 | 0.2208 | 0.302 |
Echinococcus granulosus | frizzled | 0.0077 | 0.2208 | 0.302 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2208 | 0.302 |
Brugia malayi | Fz domain containing protein | 0.0077 | 0.2208 | 0.302 |
Echinococcus granulosus | secreted frizzled protein | 0.0077 | 0.2208 | 0.302 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2208 | 0.302 |
Echinococcus granulosus | smoothened | 0.0077 | 0.2208 | 0.302 |
Brugia malayi | Unc-6 protein precursor | 0.0224 | 0.7312 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.7312 | 1 |
Echinococcus multilocularis | netrin 1 | 0.0224 | 0.7312 | 1 |
Echinococcus multilocularis | frizzled | 0.0077 | 0.2208 | 0.302 |
Brugia malayi | Fz domain containing protein | 0.0077 | 0.2208 | 0.302 |
Schistosoma mansoni | secreted frizzled-related protein | 0.0077 | 0.2208 | 0.302 |
Echinococcus multilocularis | frizzled 4 | 0.0077 | 0.2208 | 0.302 |
Loa Loa (eye worm) | frizzled/Smoothened family membrane region containing protein | 0.0077 | 0.2208 | 0.302 |
Loa Loa (eye worm) | sfrp2 | 0.0077 | 0.2208 | 0.302 |
Echinococcus granulosus | frizzled | 0.0077 | 0.2208 | 0.302 |
Echinococcus multilocularis | secreted frizzled protein | 0.0077 | 0.2208 | 0.302 |
Echinococcus granulosus | netrin 1 | 0.0224 | 0.7312 | 1 |
Schistosoma mansoni | frizzled-like receptor | 0.0077 | 0.2208 | 0.302 |
Echinococcus granulosus | frizzled 4 | 0.0077 | 0.2208 | 0.302 |
Echinococcus multilocularis | frizzled 5 | 0.0077 | 0.2208 | 0.302 |
Echinococcus granulosus | secreted frizzled protein 5 | 0.0077 | 0.2208 | 0.302 |
Echinococcus multilocularis | frizzled 10 | 0.0077 | 0.2208 | 0.302 |
Schistosoma mansoni | frizzled | 0.0077 | 0.2208 | 0.302 |
Brugia malayi | Frizzled/Smoothened family membrane region containing protein | 0.0077 | 0.2208 | 0.302 |
Echinococcus multilocularis | secreted frizzled protein | 0.0077 | 0.2208 | 0.302 |
Echinococcus multilocularis | smoothened | 0.0077 | 0.2208 | 0.302 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0065 uM | Modulator activity at GAL4-tagged human RORgammat ligand binding domain expressed HEK293T cells by luciferase reporter gene assay | ChEMBL. | 25147600 |
Inhibition (binding) | = 85 % | Modulator activity at GAL4-tagged human RORgammat ligand binding domain expressed HEK293T cells by luciferase reporter gene assay relative to untreated control | ChEMBL. | 25147600 |
Kd (binding) | = 0.00083 uM | Binding affinity to human wild type RORgammat ligand binding domain expressed in Escherichia coli by thermofluor assay | ChEMBL. | 25147600 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.