Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0182 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0082 | 0.4434 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0001 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0082 | 0.4434 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0001 | 0 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase Chk2 | 0.0082 | 0.4434 | 1 |
Leishmania major | serine-threonine protein kinase-like protein | 0.0001 | 0 | 0.5 |
Trypanosoma brucei | Forkhead Kinase, putative | 0.0001 | 0 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0182 | 1 | 0.5 |
Leishmania major | protein kinase, putative | 0.0001 | 0 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0001 | 0 | 0.5 |
Leishmania major | protein kinase, putative | 0.0001 | 0 | 0.5 |
Leishmania major | protein kinase, putative | 0.0001 | 0 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0082 | 0.4434 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
KA (binding) | = 0.013 uM | Activation of cytosolic human carbonic anhydrase-7 incubated for 15 mins prior to testing by stopped-flow CO2 hydrase assay | ChEMBL. | 25082511 |
KA (binding) | = 1.25 uM | Activation of cytosolic human carbonic anhydrase-1 incubated for 15 mins prior to testing by stopped-flow CO2 hydrase assay | ChEMBL. | 25082511 |
KA (binding) | = 15.3 uM | Activation of transmembrane human carbonic anhydrase-14 incubated for 15 mins prior to testing by stopped-flow CO2 hydrase assay | ChEMBL. | 25082511 |
KA (binding) | = 21.5 uM | Activation of cytosolic human carbonic anhydrase-12 incubated for 15 mins prior to testing by stopped-flow CO2 hydrase assay | ChEMBL. | 25082511 |
KA (binding) | = 30.9 uM | Activation of cytosolic human carbonic anhydrase-2 incubated for 15 mins prior to testing by stopped-flow CO2 hydrase assay | ChEMBL. | 25082511 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.