Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Janus kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Fz domain containing protein | 0.0123 | 0.1563 | 0.2204 |
Schistosoma mansoni | secreted frizzled-related protein | 0.0123 | 0.1563 | 0.2204 |
Echinococcus multilocularis | netrin 1 | 0.0358 | 0.709 | 1 |
Echinococcus multilocularis | frizzled | 0.0123 | 0.1563 | 0.2204 |
Echinococcus multilocularis | secreted frizzled protein | 0.0123 | 0.1563 | 0.2204 |
Echinococcus granulosus | frizzled | 0.0123 | 0.1563 | 0.2204 |
Echinococcus granulosus | netrin 1 | 0.0358 | 0.709 | 1 |
Echinococcus multilocularis | frizzled 4 | 0.0123 | 0.1563 | 0.2204 |
Loa Loa (eye worm) | frizzled/Smoothened family membrane region containing protein | 0.0123 | 0.1563 | 0.2204 |
Loa Loa (eye worm) | sfrp2 | 0.0123 | 0.1563 | 0.2204 |
Echinococcus granulosus | frizzled 4 | 0.0123 | 0.1563 | 0.2204 |
Echinococcus multilocularis | frizzled 5 | 0.0123 | 0.1563 | 0.2204 |
Echinococcus granulosus | secreted frizzled protein 5 | 0.0123 | 0.1563 | 0.2204 |
Schistosoma mansoni | frizzled-like receptor | 0.0123 | 0.1563 | 0.2204 |
Echinococcus multilocularis | secreted frizzled protein | 0.0123 | 0.1563 | 0.2204 |
Brugia malayi | Frizzled/Smoothened family membrane region containing protein | 0.0123 | 0.1563 | 0.2204 |
Echinococcus multilocularis | smoothened | 0.0123 | 0.1563 | 0.2204 |
Schistosoma mansoni | frizzled | 0.0123 | 0.1563 | 0.2204 |
Echinococcus multilocularis | frizzled 10 | 0.0123 | 0.1563 | 0.2204 |
Echinococcus multilocularis | secreted frizzled protein 5 | 0.0123 | 0.1563 | 0.2204 |
Echinococcus multilocularis | frizzled | 0.0123 | 0.1563 | 0.2204 |
Echinococcus granulosus | frizzled 5 | 0.0123 | 0.1563 | 0.2204 |
Loa Loa (eye worm) | frizzled/Smoothened family membrane region containing protein | 0.0123 | 0.1563 | 0.2204 |
Brugia malayi | Frizzled/Smoothened family membrane region containing protein | 0.0123 | 0.1563 | 0.2204 |
Echinococcus granulosus | frizzled | 0.0123 | 0.1563 | 0.2204 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1563 | 0.2204 |
Schistosoma mansoni | netrin | 0.0358 | 0.709 | 1 |
Schistosoma mansoni | wnt inhibitor frzb2 | 0.0123 | 0.1563 | 0.2204 |
Schistosoma mansoni | netrin | 0.0358 | 0.709 | 1 |
Schistosoma mansoni | frizzled-like receptor | 0.0123 | 0.1563 | 0.2204 |
Echinococcus granulosus | frizzled | 0.0123 | 0.1563 | 0.2204 |
Loa Loa (eye worm) | hypothetical protein | 0.0358 | 0.709 | 1 |
Brugia malayi | Fz domain containing protein | 0.0123 | 0.1563 | 0.2204 |
Echinococcus granulosus | secreted frizzled protein | 0.0123 | 0.1563 | 0.2204 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1563 | 0.2204 |
Echinococcus granulosus | smoothened | 0.0123 | 0.1563 | 0.2204 |
Brugia malayi | Unc-6 protein precursor | 0.0358 | 0.709 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.695 uM | Inhibition of recombinant human JAK2 (808-1132 residues) using LPLDKDYYVVREPGQ as substrate by radiometric assay in presence of [33P]-gamma-ATP | ChEMBL. | 25009002 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.