Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.1465 | 0.5511 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.259 | 0.9828 | 0.9828 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.2458 | 0.9323 | 0.9483 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.2458 | 0.9323 | 1 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0045 | 0.0061 | 0.0062 |
Schistosoma mansoni | histone deacetylase hda2 | 0.1465 | 0.5511 | 0.5511 |
Loa Loa (eye worm) | hypothetical protein | 0.2458 | 0.9323 | 0.9487 |
Onchocerca volvulus | 0.0231 | 0.0774 | 0.1404 | |
Loa Loa (eye worm) | ubiquitin specific peptidase 39 | 0.0045 | 0.0061 | 0.0062 |
Echinococcus multilocularis | BRCA1 associated protein | 0.0045 | 0.0061 | 0.0061 |
Echinococcus granulosus | histone deacetylase 6 | 0.259 | 0.9828 | 0.9828 |
Echinococcus multilocularis | histone deacetylase 3 | 0.2458 | 0.9323 | 0.9323 |
Trypanosoma cruzi | histone deacetylase, putative | 0.1465 | 0.5511 | 0.5581 |
Brugia malayi | Histone deacetylase family protein | 0.259 | 0.9828 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.2458 | 0.9323 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.259 | 0.9828 | 0.9828 |
Schistosoma mansoni | family C19 non-peptidase homologue (C19 family) | 0.0045 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | ubiquitin carboxyl-terminal hydrolase | 0.0045 | 0.0061 | 0.0062 |
Trichomonas vaginalis | histone deacetylase, putative | 0.2458 | 0.9323 | 1 |
Echinococcus granulosus | histone deacetylase 8 | 0.1465 | 0.5511 | 0.5511 |
Echinococcus granulosus | BRCA1 associated protein | 0.0045 | 0.0061 | 0.0061 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 22 | 0.0045 | 0.0061 | 0.0061 |
Echinococcus multilocularis | histone deacetylase 6 | 0.2635 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.2458 | 0.9323 | 0.9487 |
Echinococcus granulosus | histone deacetylase 7 | 0.259 | 0.9828 | 0.9828 |
Echinococcus multilocularis | u4:u6.u5 tri snrnp associated protein 2 | 0.0045 | 0.0061 | 0.0061 |
Plasmodium falciparum | histone deacetylase, putative | 0.259 | 0.9828 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.2458 | 0.9323 | 0.9487 |
Entamoeba histolytica | histone deacetylase, putative | 0.2458 | 0.9323 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.2458 | 0.9323 | 1 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.1465 | 0.5511 | 0.5608 |
Leishmania major | histone deacetylase, putative | 0.259 | 0.9828 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.259 | 0.9828 | 1 |
Loa Loa (eye worm) | ubiquitin carboxyl-terminal hydrolase | 0.0045 | 0.0061 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.1125 | 0.4205 | 0.4278 |
Brugia malayi | Pre-SET motif family protein | 0.0203 | 0.0667 | 0.0678 |
Trypanosoma brucei | histone deacetylase 1 | 0.2458 | 0.9323 | 0.9483 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.259 | 0.9828 | 0.9828 |
Brugia malayi | histone deacetylase 11 | 0.1465 | 0.5511 | 0.5608 |
Echinococcus multilocularis | histone deacetylase 6 | 0.259 | 0.9828 | 0.9828 |
Trypanosoma brucei | histone deacetylase 4 | 0.259 | 0.9828 | 1 |
Plasmodium vivax | histone deacetylase, putative | 0.259 | 0.9828 | 1 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 5 | 0.0045 | 0.0061 | 0.0061 |
Echinococcus granulosus | histone deacetylase 3 | 0.2458 | 0.9323 | 0.9323 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.2458 | 0.9323 | 0.9487 |
Plasmodium falciparum | histone deacetylase 1 | 0.2458 | 0.9323 | 0.9483 |
Echinococcus granulosus | u4:u6.u5 tri snrnp associated protein 2 | 0.0045 | 0.0061 | 0.0061 |
Schistosoma mansoni | histone deacetylase | 0.2458 | 0.9323 | 0.9323 |
Trichomonas vaginalis | set domain proteins, putative | 0.0231 | 0.0774 | 0.077 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.2458 | 0.9323 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.2458 | 0.9323 | 0.9483 |
Plasmodium vivax | U4/U6.U5 tri-snRNP-associated protein 2, putative | 0.0045 | 0.0061 | 0.0062 |
Toxoplasma gondii | Zn-finger in ubiquitin-hydrolases domain-containing protein | 0.0045 | 0.0061 | 0.0062 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.1465 | 0.5511 | 0.5608 |
Trypanosoma brucei | histone deacetylase 3 | 0.259 | 0.9828 | 1 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 22 | 0.0045 | 0.0061 | 0.0061 |
Trypanosoma brucei | histone deacetylase, putative | 0.259 | 0.9828 | 1 |
Schistosoma mansoni | brca1-associated protein (brap2) | 0.0045 | 0.0061 | 0.0061 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.1465 | 0.5511 | 0.5511 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.2458 | 0.9323 | 0.9487 |
Brugia malayi | Histone deacetylase 1 | 0.2458 | 0.9323 | 0.9487 |
Plasmodium vivax | histone deacetylase 1, putative | 0.2458 | 0.9323 | 0.9487 |
Loa Loa (eye worm) | hypothetical protein | 0.117 | 0.4377 | 0.4454 |
Plasmodium vivax | histone deacetylase, putative | 0.1465 | 0.5511 | 0.5608 |
Plasmodium vivax | histone deacetylase 2, putative | 0.259 | 0.9828 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 44 (C19 family) | 0.0045 | 0.0061 | 0.0061 |
Trichomonas vaginalis | histone deacetylase, putative | 0.2458 | 0.9323 | 1 |
Loa Loa (eye worm) | BRCA1-associated protein 2 containing protein | 0.0045 | 0.0061 | 0.0062 |
Schistosoma mansoni | histone deacetylase | 0.2458 | 0.9323 | 0.9323 |
Echinococcus multilocularis | histone deacetylase 8 | 0.1465 | 0.5511 | 0.5511 |
Schistosoma mansoni | brca1-associated protein (brap2) | 0.0045 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.259 | 0.9828 | 1 |
Leishmania major | histone deacetylase, putative | 0.259 | 0.9828 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.259 | 0.9828 | 0.9828 |
Toxoplasma gondii | UBA/TS-N domain-containing protein | 0.0045 | 0.0061 | 0.0062 |
Toxoplasma gondii | ubiquitin specific protease 39 isoform 2, putative | 0.0045 | 0.0061 | 0.0062 |
Giardia lamblia | Histone deacetylase | 0.2458 | 0.9323 | 1 |
Plasmodium falciparum | histone deacetylase 2 | 0.259 | 0.9828 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.2458 | 0.9323 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.2635 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.2458 | 0.9323 | 0.9323 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.1465 | 0.5511 | 0.5608 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.2458 | 0.9323 | 0.9487 |
Leishmania major | histone deacetylase, putative | 0.2458 | 0.9323 | 0.9483 |
Loa Loa (eye worm) | ubiquitin carboxyl-terminal hydrolase | 0.0045 | 0.0061 | 0.0062 |
Schistosoma mansoni | ubiquitin-specific peptidase 5 (C19 family) | 0.0045 | 0.0061 | 0.0061 |
Trichomonas vaginalis | histone deacetylase, putative | 0.2458 | 0.9323 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0045 | 0.0061 | 0.0062 |
Plasmodium vivax | ubiquitin carboxyl-terminal hydrolase 13, putative | 0.0045 | 0.0061 | 0.0062 |
Trypanosoma brucei | histone deacetylase 2 | 0.1465 | 0.5511 | 0.5581 |
Onchocerca volvulus | Uncharacterized RING finger protein homolog | 0.0045 | 0.0061 | 0.011 |
Echinococcus multilocularis | histone deacetylase 1 | 0.2458 | 0.9323 | 0.9323 |
Brugia malayi | BRCA1-associated protein 2 containing protein | 0.0045 | 0.0061 | 0.0062 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.259 | 0.9828 | 0.9828 |
Loa Loa (eye worm) | histone deacetylase | 0.259 | 0.9828 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.259 | 0.9828 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.259 | 0.9828 | 1 |
Leishmania major | histone deacetylase, putative | 0.2458 | 0.9323 | 0.9483 |
Trichomonas vaginalis | histone deacetylase, putative | 0.2458 | 0.9323 | 1 |
Echinococcus granulosus | histone deacetylase | 0.259 | 0.9828 | 0.9828 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0045 | 0.0061 | 0.0062 |
Echinococcus multilocularis | histone deacetylase | 0.259 | 0.9828 | 0.9828 |
Trypanosoma cruzi | histone deacetylase, putative | 0.1465 | 0.5511 | 0.5581 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0045 | 0.0061 | 0.0062 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0203 | 0.0667 | 0.0678 |
Loa Loa (eye worm) | hypothetical protein | 0.1465 | 0.5511 | 0.5608 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.2458 | 0.9323 | 0.9487 |
Trypanosoma cruzi | histone deacetylase, putative | 0.259 | 0.9828 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.259 | 0.9828 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (binding) | = 0.47 /M/s | Inhibition of recombinant Plasmodium falciparum GAPDH expressed in Escherichia coli assessed as ratio of kinact to Ki by Kitz-Wilson double-reciprocal plot | ChEMBL. | 25137375 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.