Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.0251 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0251 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0251 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0251 | 0.5 | 0.5 | |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.0251 | 0.5 | 0.5 |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0251 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0251 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 78 % | Inhibition of recombinant His-tagged PDE4B1 (unknown origin) expressed in Sf9 cells at 30 uM pre-incubated for 15 mins before cAMP substrate addition by luminescence assay | ChEMBL. | 25171781 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.