Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Protein Wnt-04 | 0.0199 | 0.2152 | 0.2939 |
Echinococcus multilocularis | 0.0105 | 0.0931 | 0.1272 | |
Schistosoma mansoni | wnt related | 0.0199 | 0.2152 | 0.1821 |
Schistosoma mansoni | wnt related | 0.0199 | 0.2152 | 0.1821 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0324 | 0.3772 | 0.019 |
Echinococcus multilocularis | frizzled | 0.0206 | 0.2241 | 0.3059 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.2152 | 0.2939 |
Schistosoma mansoni | netrin | 0.0598 | 0.7324 | 1 |
Loa Loa (eye worm) | wnt-4 protein | 0.0199 | 0.2152 | 0.2939 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.2241 | 0.3059 |
Echinococcus granulosus | insulin receptor | 0.0111 | 0.1001 | 0.1366 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0347 | 0.4067 | 0.4849 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.2152 | 0.2939 |
Echinococcus multilocularis | frizzled 4 | 0.0206 | 0.2241 | 0.3059 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.2152 | 0.2939 |
Echinococcus multilocularis | WNT | 0.0199 | 0.2152 | 0.2939 |
Schistosoma mansoni | netrin | 0.0598 | 0.7324 | 1 |
Echinococcus granulosus | Protein Wnt-5 | 0.0199 | 0.2152 | 0.2939 |
Schistosoma mansoni | frizzled-like receptor | 0.0206 | 0.2241 | 0.1961 |
Echinococcus granulosus | netrin 1 | 0.0598 | 0.7324 | 1 |
Schistosoma mansoni | wnt inhibitor frzb2 | 0.0206 | 0.2241 | 0.1961 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0185 | 0.1962 | 0.2679 |
Echinococcus granulosus | secreted frizzled protein | 0.0206 | 0.2241 | 0.3059 |
Echinococcus multilocularis | insulin receptor | 0.0111 | 0.1001 | 0.1366 |
Echinococcus multilocularis | frizzled 5 | 0.0206 | 0.2241 | 0.3059 |
Echinococcus multilocularis | wingless type MMTV integration site family | 0.0199 | 0.2152 | 0.2939 |
Echinococcus multilocularis | smoothened | 0.0206 | 0.2241 | 0.3059 |
Echinococcus granulosus | frizzled 5 | 0.0206 | 0.2241 | 0.3059 |
Schistosoma mansoni | tyrosine kinase | 0.0181 | 0.1912 | 0.1442 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0342 | 0.4006 | 0.547 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0185 | 0.1962 | 0.2679 |
Loa Loa (eye worm) | CWN-2 protein | 0.0199 | 0.2152 | 0.2939 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0185 | 0.1962 | 0.2679 |
Brugia malayi | Unc-6 protein precursor | 0.0598 | 0.7324 | 1 |
Loa Loa (eye worm) | frizzled/Smoothened family membrane region containing protein | 0.0206 | 0.2241 | 0.3059 |
Brugia malayi | wnt family protein | 0.0199 | 0.2152 | 0.1821 |
Echinococcus granulosus | frizzled | 0.0206 | 0.2241 | 0.3059 |
Echinococcus granulosus | Protein Wnt-111 | 0.0199 | 0.2152 | 0.2939 |
Echinococcus granulosus | secreted frizzled protein 5 | 0.0206 | 0.2241 | 0.3059 |
Echinococcus granulosus | frizzled | 0.0206 | 0.2241 | 0.3059 |
Echinococcus multilocularis | WNT | 0.0199 | 0.2152 | 0.2939 |
Schistosoma mansoni | wnt related | 0.0199 | 0.2152 | 0.1821 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.2152 | 0.2939 |
Brugia malayi | Wnt-4 protein precursor | 0.0199 | 0.2152 | 0.1821 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.2241 | 0.3059 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.2152 | 0.2939 |
Echinococcus multilocularis | protein Wnt 1 | 0.0199 | 0.2152 | 0.2939 |
Echinococcus multilocularis | protein Wnt 2 | 0.0199 | 0.2152 | 0.2939 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0111 | 0.1001 | 0.1366 |
Schistosoma mansoni | frizzled-like receptor | 0.0206 | 0.2241 | 0.1961 |
Echinococcus granulosus | Protein Wnt-11b | 0.0199 | 0.2152 | 0.2939 |
Echinococcus multilocularis | frizzled 10 | 0.0206 | 0.2241 | 0.3059 |
Schistosoma mansoni | tyrosine kinase | 0.0185 | 0.1962 | 0.1521 |
Brugia malayi | Fz domain containing protein | 0.0206 | 0.2241 | 0.1961 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0347 | 0.4067 | 0.5553 |
Echinococcus multilocularis | secreted frizzled protein 5 | 0.0206 | 0.2241 | 0.3059 |
Schistosoma mansoni | wnt-5 | 0.0199 | 0.2152 | 0.1821 |
Schistosoma mansoni | secreted frizzled-related protein | 0.0206 | 0.2241 | 0.1961 |
Brugia malayi | Frizzled/Smoothened family membrane region containing protein | 0.0206 | 0.2241 | 0.1961 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0342 | 0.4006 | 0.4753 |
Brugia malayi | Frizzled/Smoothened family membrane region containing protein | 0.0206 | 0.2241 | 0.1961 |
Brugia malayi | wnt family protein | 0.0199 | 0.2152 | 0.1821 |
Brugia malayi | wnt family protein | 0.0199 | 0.2152 | 0.1821 |
Loa Loa (eye worm) | hypothetical protein | 0.0598 | 0.7324 | 1 |
Echinococcus multilocularis | frizzled | 0.0206 | 0.2241 | 0.3059 |
Brugia malayi | Fz domain containing protein | 0.0206 | 0.2241 | 0.1961 |
Loa Loa (eye worm) | sfrp2 | 0.0206 | 0.2241 | 0.3059 |
Schistosoma mansoni | tyrosine kinase | 0.0181 | 0.1912 | 0.1442 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0342 | 0.4006 | 0.547 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0342 | 0.4006 | 0.547 |
Echinococcus multilocularis | secreted frizzled protein | 0.0206 | 0.2241 | 0.3059 |
Schistosoma mansoni | tyrosine kinase | 0.0342 | 0.4006 | 0.4753 |
Echinococcus granulosus | protein Wnt 1 | 0.0199 | 0.2152 | 0.2939 |
Brugia malayi | wnt family protein | 0.0199 | 0.2152 | 0.1821 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0111 | 0.1001 | 0.1366 |
Echinococcus multilocularis | netrin 1 | 0.0598 | 0.7324 | 1 |
Schistosoma mansoni | frizzled | 0.0206 | 0.2241 | 0.1961 |
Loa Loa (eye worm) | Wnt2 protein | 0.0199 | 0.2152 | 0.2939 |
Schistosoma mansoni | tyrosine kinase | 0.0181 | 0.1912 | 0.1442 |
Echinococcus granulosus | protein Wnt 2 | 0.0199 | 0.2152 | 0.2939 |
Brugia malayi | Wnt-2 protein precursor | 0.0199 | 0.2152 | 0.1821 |
Schistosoma mansoni | tyrosine kinase | 0.0185 | 0.1962 | 0.1521 |
Schistosoma mansoni | wnt related | 0.0199 | 0.2152 | 0.1821 |
Echinococcus granulosus | smoothened | 0.0206 | 0.2241 | 0.3059 |
Echinococcus granulosus | frizzled | 0.0206 | 0.2241 | 0.3059 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0111 | 0.1001 | 0.1366 |
Loa Loa (eye worm) | frizzled/Smoothened family membrane region containing protein | 0.0206 | 0.2241 | 0.3059 |
Echinococcus granulosus | frizzled 4 | 0.0206 | 0.2241 | 0.3059 |
Echinococcus multilocularis | wnt family member wnt11 2 | 0.0199 | 0.2152 | 0.2939 |
Echinococcus multilocularis | secreted frizzled protein | 0.0206 | 0.2241 | 0.3059 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (ADMET) | = 42.95 % | Cytotoxicity against mouse RAW264.7 cells at 100 uM after 48 hrs by MTT assay | ChEMBL. | 25127151 |
MIC (functional) | = 1.9 uM | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 7 days by microplate alamar blue assay | ChEMBL. | 25127151 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.