Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, muscarinic 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0144 | 0 | 0.5 |
Onchocerca volvulus | 0.0241 | 0.075 | 0.5 | |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0144 | 0 | 0.5 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0597 | 0.3493 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0144 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0597 | 0.3493 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1149 | 0.7754 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0144 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.144 | 1 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0597 | 0.3493 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0597 | 0.3493 | 1 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.057 | 0.3285 | 0.3344 |
Trichomonas vaginalis | conserved hypothetical protein | 0.144 | 1 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0144 | 0 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0144 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0144 | 0 | 0.5 |
Onchocerca volvulus | Putative sulfate transporter | 0.0241 | 0.075 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0144 | 0 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0306 | 0.1247 | 0.031 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0144 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
%max (functional) | = 84 % | Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay relative to acetylcholine | ChEMBL. | 25147929 |
EC50 (functional) | = 5.67 | Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay | ChEMBL. | 25147929 |
EC50 (functional) | = 2.1 uM | Positive allosteric modulator activity at human muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay | ChEMBL. | 25147929 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.