Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | DNA polymerase eta, putative | 0.0049 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0049 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0049 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2319 | 0.2319 |
Echinococcus multilocularis | dna polymerase eta | 0.0049 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0049 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.2319 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.2319 | 0.2319 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0034 | 0.4775 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.2319 | 0.2319 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.2319 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0034 | 0.4775 | 0.4775 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.2319 | 0.2319 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0049 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.2319 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.2319 | 0.2319 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0027 | 0.2319 | 0.2319 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0034 | 0.4775 | 0.4775 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 34.81 % | Inhibition of ovine COX1 assessed as reduction in PGF2alpha formation at 10 uM incubated for 18 hrs by enzyme immunoassay | ChEMBL. | 25219899 |
Inhibition (binding) | = 69.14 % | Inhibition of ovine COX2 assessed as reduction in PGF2alpha formation at 10 uM incubated for 18 hrs by enzyme immunoassay | ChEMBL. | 25219899 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.