Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | Starlite/ChEMBL | References |
Homo sapiens | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | 163 aa | 161 aa | 26.1 % |
Leishmania mexicana | hypothetical protein, conserved | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | 163 aa | 169 aa | 29.0 % |
Candida albicans | one of three chitinase genes similar to S. cerevisiae CTS1 (YLR286C) | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | 163 aa | 146 aa | 22.6 % |
Trypanosoma cruzi | hypothetical protein, conserved | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | 163 aa | 140 aa | 25.7 % |
Leishmania infantum | hypothetical protein, conserved | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | 163 aa | 170 aa | 27.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0322 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.8576 | 1 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0088 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0322 | 1 | 1 |
Toxoplasma gondii | fructose-bisphosphate aldolase, putative | 0.0088 | 0 | 0.5 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0088 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0322 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0288 | 0.8576 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0322 | 1 | 0.5 |
Plasmodium falciparum | fructose-bisphosphate aldolase | 0.0088 | 0 | 0.5 |
Plasmodium vivax | fructose 1,6-bisphosphate aldolase, putative | 0.0088 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0288 | 0.8576 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0288 | 0.8576 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0288 | 0.8576 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0288 | 0.8576 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0288 | 0.8576 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0288 | 0.8576 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0288 | 0.8576 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0288 | 0.8576 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0288 | 0.8576 | 1 |
Trypanosoma brucei | nucleoside 2-deoxyribosyltransferase | 0.0322 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0288 | 0.8576 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.8576 | 1 |
Trypanosoma cruzi | hypothetical protein | 0.0322 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein | 0.0322 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | > 90 % | Cytotoxicity against human MCF7 cells at 10 uM after 72 hrs by MTT assay | ChEMBL. | 25108359 |
Ki (binding) | = 1.5 uM | Inhibition of rat DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometrically | ChEMBL. | 25108359 |
Ki (binding) | = 1.5 uM | Inhibition of human DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometrically | ChEMBL. | 25108359 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.