Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | folate receptor 1 (adult) | Starlite/ChEMBL | References |
Homo sapiens | folate receptor 2 (fetal) | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 46 (folate transporter), member 1 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 19 (folate transporter), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | Major facilitator superfamily general substrate transporter | Get druggable targets OG5_133613 | All targets in OG5_133613 |
Schistosoma japonicum | IPR011701,Major facilitator superfamily MFS_1,domain-containing | Get druggable targets OG5_133613 | All targets in OG5_133613 |
Echinococcus granulosus | folate receptor beta | Get druggable targets OG5_133376 | All targets in OG5_133376 |
Schistosoma japonicum | Folate receptor beta precursor, putative | Get druggable targets OG5_133376 | All targets in OG5_133376 |
Echinococcus multilocularis | Major facilitator superfamily, general substrate transporter | Get druggable targets OG5_133613 | All targets in OG5_133613 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_133613 | All targets in OG5_133613 |
Echinococcus multilocularis | folate receptor beta | Get druggable targets OG5_133376 | All targets in OG5_133376 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tissue type plasminogen activator | 0.0572 | 0.1066 | 0.1066 |
Brugia malayi | Protein kinase domain containing protein | 0.0572 | 0.1066 | 1 |
Echinococcus multilocularis | folate receptor beta | 0.1006 | 1 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0572 | 0.1066 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0572 | 0.1066 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0572 | 0.1066 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0572 | 0.1066 | 1 |
Onchocerca volvulus | 0.0572 | 0.1066 | 1 | |
Leishmania major | hypothetical protein, conserved | 0.0572 | 0.1066 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 0.1066 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0572 | 0.1066 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0572 | 0.1066 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0572 | 0.1066 | 0.1066 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0572 | 0.1066 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 27.4 nM | Inhibition of FRalpha (unknown origin) expressed in Chinese hamster RT16 cells assessed as cell growth inhibition incubated up to 96 hrs by Celltiter-blue cell viability assay | ChEMBL. | 25234128 |
IC50 (binding) | > 1000 nM | Inhibition of PCFT (unknown origin) expressed in Chinese hamster R2/PCFT4 cells assessed as cell growth inhibition incubated up to 96 hrs by Celltiter-blue cell viability assay | ChEMBL. | 25234128 |
IC50 (binding) | > 1000 nM | Inhibition of FRbeta (unknown origin) expressed in Chinese hamster D4 cells assessed as cell growth inhibition incubated up to 96 hrs in presence of 200 nM folic acid by Celltiter-blue cell viability assay | ChEMBL. | 25234128 |
IC50 (binding) | > 1000 nM | Inhibition of FRbeta (unknown origin) expressed in Chinese hamster D4 cells assessed as cell growth inhibition incubated up to 96 hrs by Celltiter-blue cell viability assay | ChEMBL. | 25234128 |
IC50 (binding) | > 1000 nM | Inhibition of FRalpha (unknown origin) expressed in Chinese hamster RT16 cells assessed as cell growth inhibition incubated up to 96 hrs in presence of 200 nM folic acid by Celltiter-blue cell viability assay | ChEMBL. | 25234128 |
IC50 (binding) | > 1000 nM | Inhibition of RFC (unknown origin) expressed in Chinese hamster PC43-10 cells assessed as cell growth inhibition incubated up to 96 hrs by Celltiter-blue cell viability assay | ChEMBL. | 25234128 |
IC50 (functional) | > 1000 nM | Cytotoxicity against human KB cells assessed as cell growth inhibition incubated up to 96 hrs in presence of 200 nM folic acid by Celltiter-blue cell viability assay | ChEMBL. | 25234128 |
Inhibition (binding) | Inhibition of [3H]folic acid binding to FRalpha (unknown origin) expressed in Chinese hamster RT16 cells | ChEMBL. | 25234128 | |
Inhibition (binding) | Inhibition of [3H]folic acid binding to FRbeta (unknown origin) expressed in Chinese hamster D4 cells | ChEMBL. | 25234128 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 25234128 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.