Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.2726 | 0 | 0.5 |
Onchocerca volvulus | 0.2966 | 1 | 0.5 | |
Leishmania major | fatty-acid desaturase, putative | 0.2966 | 1 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.2726 | 0 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.2726 | 0 | 0.5 |
Onchocerca volvulus | 0.2966 | 1 | 0.5 | |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2966 | 1 | 1 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.2966 | 1 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.2726 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 2 ug ml-1 | Antibacterial activity against Escherichia coli DH52 by two-fold serial dilution method | ChEMBL. | 25173851 |
MIC (functional) | = 32 ug ml-1 | Antifungal activity against Saccharomyces cerevisiae after 24 hrs by microbroth dilution method | ChEMBL. | 25173851 |
MIC (functional) | = 128 ug ml-1 | Antifungal activity against Candida albicans ATCC 76615 after 24 hrs by microbroth dilution method | ChEMBL. | 25173851 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.