Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Furin-like cysteine rich region family protein | 0.0367 | 0.3027 | 0.3027 |
Schistosoma mansoni | tyrosine kinase | 0.0236 | 0.1783 | 0.1783 |
Echinococcus multilocularis | Cyclin dependent kinase 2 associated protein | 0.0137 | 0.0845 | 0.2793 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.0845 | 0.0845 |
Onchocerca volvulus | 0.0716 | 0.6332 | 0.9581 | |
Schistosoma mansoni | cell adhesion molecule | 0.0064 | 0.0149 | 0.0149 |
Schistosoma mansoni | tyrosine kinase | 0.0216 | 0.1599 | 0.1599 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0792 | 0.7057 | 0.7057 |
Echinococcus granulosus | twitchin | 0.0063 | 0.0146 | 0.0481 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.1103 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1103 | 1 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0076 | 0.0266 | 0.0879 |
Schistosoma mansoni | deleted in oral cancer 1/cdk2-associated protein-like | 0.0137 | 0.0845 | 0.0845 |
Brugia malayi | hypothetical protein | 0.0448 | 0.3795 | 0.3795 |
Schistosoma mansoni | tyrosine kinase | 0.0229 | 0.1722 | 0.1722 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0367 | 0.3027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0149 | 0.0149 |
Brugia malayi | Protein kinase domain containing protein | 0.0236 | 0.1783 | 0.1783 |
Echinococcus multilocularis | 0.0109 | 0.0582 | 0.1921 | |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0367 | 0.3027 | 0.3027 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0229 | 0.1722 | 0.569 |
Brugia malayi | Protein kinase domain containing protein | 0.0084 | 0.0345 | 0.0345 |
Echinococcus granulosus | roundabout 2 | 0.0076 | 0.0266 | 0.0879 |
Echinococcus granulosus | Cyclin dependent kinase 2 associated protein | 0.0137 | 0.0845 | 0.2793 |
Schistosoma mansoni | tyrosine kinase | 0.0216 | 0.1599 | 0.1599 |
Echinococcus multilocularis | insulin receptor | 0.0236 | 0.1783 | 0.5891 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0229 | 0.1722 | 0.569 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0236 | 0.1783 | 0.1783 |
Schistosoma mansoni | tyrosine kinase | 0.0216 | 0.1599 | 0.1599 |
Schistosoma mansoni | tyrosine kinase | 0.0236 | 0.1783 | 0.1783 |
Echinococcus granulosus | neuroglian | 0.006 | 0.0117 | 0.0386 |
Schistosoma mansoni | tyrosine kinase | 0.0229 | 0.1722 | 0.1722 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0229 | 0.1722 | 0.569 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0064 | 0.0149 | 0.0493 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0222 | 0.0222 |
Schistosoma mansoni | nephrin | 0.006 | 0.0117 | 0.0117 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0236 | 0.1783 | 0.5891 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0741 | 0.6572 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0792 | 0.7057 | 0.7057 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.1722 | 0.5 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0236 | 0.1783 | 0.5891 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0266 | 0.0266 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0367 | 0.3027 | 1 |
Echinococcus multilocularis | neuroglian | 0.006 | 0.0117 | 0.0386 |
Schistosoma mansoni | tyrosine kinase | 0.0367 | 0.3027 | 0.3027 |
Echinococcus granulosus | insulin receptor | 0.0236 | 0.1783 | 0.5891 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (ADMET) | > 100 uM | Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by CellTiter-Blue assay | ChEMBL. | 25148591 |
Inhibition (binding) | < 15 % | Inhibition of Dengue virus serotype 2 NS2B-NS3 protease at 50 uM | ChEMBL. | 25148591 |
Inhibition (binding) | < 15 % | Inhibition of West Nile virus NS2B-NS3 protease at 50 uM | ChEMBL. | 25148591 |
Inhibition (binding) | < 15 % | Inhibition of Bovine thrombin using Boc-Val-Pro-Arg-AMC as substrate compound preincubated at 25 uM for 15 mins by fluorescence assay | ChEMBL. | 25148591 |
Inhibition (binding) | < 15 % | Inhibition of human MetAP at 25 uM after 20 mins by HPLC analysis | ChEMBL. | 25148591 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.